Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women (2018)
- Frontiers in Microbiology
(A1 Refereed original research article in a scientific journal) - The macrophage mannose receptor regulate mannan-induced psoriasis, psoriatic arthritis, and rheumatoid arthritis-like disease models (2018)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis (2018)
- Journal of Neuroinflammation
(A1 Refereed original research article in a scientific journal) - Allergen-Induced CD4(+) T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells (2017)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Amine oxidase activity regulates the development of pulmonary fibrosis (2017)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Comparison of Ga-68-DOTA-Siglec-9 and F-18-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry (2017)
- Contrast Media and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy (2017)
- Journal of Molecular Medicine
(A1 Refereed original research article in a scientific journal) - Exploring the radiosynthesis and in vitro characteristics of [Ga-68]Ga-DOTA-Siglec-9 (2017)
- Journal of Labelled Compounds and Radiopharmaceuticals
(A1 Refereed original research article in a scientific journal) - Faecalibacterium prausnitzii Treatment Improves Hepatic Health and Reduces Adipose Tissue Inflammation in High-fat Fed Mice (2017)
- ISME Journal
(A1 Refereed original research article in a scientific journal) - Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors (2017)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration (2017)
- Hepatology
(A1 Refereed original research article in a scientific journal) - Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer (2017)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy (2017)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study (2017)
- Journal of Internal Medicine
(A1 Refereed original research article in a scientific journal) - Regulation of CD73 in the development of lower limb atherosclerosis (2017)
- Purinergic Signalling
(A1 Refereed original research article in a scientific journal) - Role of stabilin-1 in chronic liver tissue injury and repair (2017)
- Lancet
(Other publication) - Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice (2017)
- Arthritis Research and Therapy
(A1 Refereed original research article in a scientific journal) - Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis (2016)
- European Review for Medical and Pharmacological Sciences
(A1 Refereed original research article in a scientific journal) - Circulating Cytokines Predict the Development of Insulin Resistance in a Prospective Finnish Population Cohort (2016)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Compared to Intermittant Claudication Critical Limb Ischemia Is Associated with Elevated Levels of Cytokines (2016)
- PLoS ONE
(A1 Refereed original research article in a scientific journal)