Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence (2016)
- International Journal of Epidemiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Endothelial Adhesion Molecules in the Lymphatic Vasculature (2016) Encyclopedia of Immunobiology Salmi Marko, Jalkanen Sirpa
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human (2016)
- Osteoarthritis and Cartilage
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome (2016)
- American Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility (2016)
- eLife
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer (2016)
- OncoImmunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic (2016)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - How Intravitreal Ecto-5 nucleotidase/CD73 and Adenylate kinase-1 Contribute to Ocular Nucleotide Homeostasis and Are Modulated in Patients with Diabetic Retinopathy (2016)
- Ophthalmologica
(O2 Muu julkaisu ) - Hypoxia-induced inflammation and purinergic signaling in cross clamping the human aorta (2016)
- SpringerPlus
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques (2016)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Leukocyte trafficking is not affected by multikinase inhibitors sunitinib or sorafenib in mice (2016)
- International Journal of Cancer
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence (2016)
- BMC Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Monocyte stabilin-1 suppresses the activation of Th1 lymphocytes (2016)
- Journal of Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Multivalent Interactions of Human Primary Amine Oxidase with the V and C22 Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity (2016)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Simvastatin use associated with low intraocular ADP levels in patients with sight-threatening diabetic retinopathy (2016)
- Graefe's Archive for Clinical and Experimental Ophthalmology
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Soluble CD73 in Critically Ill Septic Patients Data from the Prospective FINNAKI Study (2016)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury (2016)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides (2016)
- Bioconjugate Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The role of CD73 on afferent lymphatics (2016)
- Scandinavian Journal of Immunology
(O2 Muu julkaisu ) - Thymocytes in Lyve1-CRE/S1pr1(f/f) Mice accumulate in the Thymus due to cell-intrinsic loss of sphingosine-1-Phosphate receptor expression (2016)
- Frontiers in immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )