Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. (2009)
- Blood
(A1 Refereed original research article in a scientific journal) - CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis (2008)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis (2008)
- Journal of Immunology Research
(A1 Refereed original research article in a scientific journal) - Effects of PEGylation to the stability and affinity of Ga-68-DOTA-peptides for VAP-1 targeting (2008)
- European Journal of Nuclear Medicine and Molecular Imaging
(Other publication) - IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier (2008)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Inhibition of semicarbazide-sensitive amine oxidases decreases lymphocyte infiltration in the early phases of rat liver allograft rejection (2008)
- International Journal of Immunopathology and Pharmacology
(A1 Refereed original research article in a scientific journal) - Vascular adhesion protein-1 in human ischaemic stroke (2008)
- Neuropathology and Applied Neurobiology
(A1 Refereed original research article in a scientific journal) - Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets (2007)
- American Journal of Pathology
(A1 Refereed original research article in a scientific journal) - Mechanism of action of IFN-beta in the treatment of multiple sclerosis - A special reference to CD73 and adenosine (2007)
- Annals of the New York Academy of Sciences
(A4 Refereed article in a conference publication ) - VAP-1-Deficient mice display defects in mucosal immunity and antimicrobial responses: Implications for antiadhesive applications (2007)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor immunity (2006)
- Blood
(A1 Refereed original research article in a scientific journal) - Fas costimulation of naive CD4 T cells is controlled by NF-kappa B signaling and caspase activity (2006)
- Journal of Leukocyte Biology
(A1 Refereed original research article in a scientific journal) - Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes (2006)
- American Journal of Physiology : Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo (2006)
- Arthritis and Rheumatism
(A1 Refereed original research article in a scientific journal) - Vimentin function in lymphocyte adhesion and transcellular migration (2006)
- Nature Cell Biology
(A1 Refereed original research article in a scientific journal) - Molecular identification of PAL-E, a widely used endothelial-cell marker (2005)
- Blood
(A1 Refereed original research article in a scientific journal) - CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium (2004)
- Blood
(A1 Refereed original research article in a scientific journal) - IFN-alpha induced adenosine production on the endothelium: A mechanism mediated by CD73 (ecto-5 '-nucleotidase) up-regulation (2004)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by Ecto-5'-nucleotidase/CD73-dependent mechanism. (2003)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. (2002)
- Biochemical Journal
(A1 Refereed original research article in a scientific journal)