Francisco Lopez Picon
PhD
francisco.lopez@utu.fi +358 29 450 3840 +358 50 356 2885 Tykistökatu 6 Turku : 4032 : https://orcid.org/0000-0002-3871-1735 |
Preclinical PET imaging, Neuropharmacology, Animal models of CNS diseases.
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- Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine (2019)
- Molecular Imaging and Biology
- [18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease (2018)
- Nuclear Medicine and Biology
- 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation (2018)
- Nuclear Medicine and Biology
- [F-18]FMPEP-d(2) PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease (2018)
- Neurobiology of Aging
- Neuroinflammation appears early and then plateaus in a mouse model of Alzheimer's disease shown by PET imaging (2018)
- Journal of Nuclear Medicine
- Applicability of [C-11]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model (2017)
- Neurobiology of Aging
- Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging (2017)
- Journal of Cerebral Blood Flow and Metabolism
- Luminometric Nanoparticle-Based Assay for High Sensitivity Detection of β-Amyloid Aggregation (2017)
- Analytical Chemistry
- Radiosynthesis and Preclinical Evaluation of [F-18]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats (2017)
- Molecular Imaging and Biology
- Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using F-18-GE-179 and F-18-GE-194 Autoradiography (2016)
- Journal of Nuclear Medicine
- Electrophilic fluorination and preclinical evaluation of a novel [F-18]DPA-714 analogue, [F-18]F-DPA (2015)
- Journal of Labelled Compounds and Radiopharmaceuticals
- Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells (2015)
- Journal of Neuroinflammation
- PET imaging and ex vivo brain autoradiography in a mouse model of Alzheimers disease using the TSPO tracers [F-18]DPA-714 and [F-18]F-DPA (2015)
- Journal of Labelled Compounds and Radiopharmaceuticals
- In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol (2014)
- EJNMMI Research
- Brain uptake of novel NMDA and GABAergic PET tracers in a Model of Traumatic Brain Injury in Rat (2013)
- European Journal of Nuclear Medicine and Molecular Imaging
- Longitudinal Amyloid Imaging in Mouse Brain with C-11-PIB: Comparison of APP23, Tg2576, and APP(swe)-PS1(dE9) Mouse Models of Alzheimer Disease (2013)
- Journal of Nuclear Medicine
- Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis (2013)
- Brain Research
- Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease (2012)
- European Journal of Nuclear Medicine and Molecular Imaging
- Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death (2011)
- Neuropharmacology
- Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus (2011)
- Journal of Neuroinflammation
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