Arto Pulliainen
principal investigator, PhD
arto.pulliainen@utu.fi +358 40 158 6044 Kiinamyllynkatu 10 Turku Office: C410 ORCID identifier: https://orcid.org/0000-0002-9361-8963 |
bacteriology; cell biology; bacterial toxins; protein chemistry; drug development
Principal investigator (2015-, University of Turku, Turku, Finland)
Docent / Adjunct professor (2012-, University of Helsinki, Helsinki, Finland)
Post doc (2006-2014, University of Turku, Turku, Finland and Biozentrum, Basel, Switzerland)
PhD (2006, University of Turku, Turku, Finland)
Doctoral student (2001-2006, University of Turku, Turku, Finland)
MSc (2001, University of Oulu, Oulu, Finland)
Turku Cellular Microbiology Laboratory (TCML) studies the interaction of bacterial pathogens with their host cells at molecular level. Our research is focused on proteins, in particular on enzymes, of the bacterial pathogen and of the host cell that are key molecular players shaping the development and severity of an infectious disease. Our goal is to gain detailed molecular knowledge of the protein functions allowing development of targeted pharmaceuticals to prevent and treat infectious diseases.
Funding sources:
Academy of Finland, Novo Nordisk Foundation, Jane and Aatos Erkko Foundation, Sigrid Jusélius Foundation, Finnish Cultural Foundation, The Finnish Society of Sciences and Letters, Jenny and Antti Wihuri Foundation, Emil Aaltonen Foundation, Turku University Foundation, Turku Doctoral Programme of Molecular Medicine (TuDMM), Erasmus+
bacteriology; cell biology; protein chemistry; molecular biology
- ADP-ribosyltransferase-based biocatalysis of non-hydrolyzable NAD+ analogs (2025)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Pathogenic bacterial taxa constitute a substantial portion of fecal microbiota in common migratory bats and birds in Europe (2025)
- Microbiology spectrum
(A1 Refereed original research article in a scientific journal) - Alpha-1 antitrypsin inhibits pertussis toxin (2024)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis (2024)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Identification and characterization of an endogenous human protein, α1-antitrypsin, as a novel inhibitor of the Bordetella Pertussis toxin (2024)
- Naunyn-Schmiedeberg's Archives of Pharmacology
(Other publication) - Slow-lived birds and bats carry higher pathogen loads (2024)
- One Earth
(A1 Refereed original research article in a scientific journal) - The Chaperonin TRiC/CCT Inhibitor HSF1A Protects Cells from Intoxication with Pertussis Toxin (2024)
- Toxins
(A1 Refereed original research article in a scientific journal) - Continental-scale climatic gradients of pathogenic microbial taxa in birds and bats (2023)
- Ecography
(A1 Refereed original research article in a scientific journal) - DNA Nanoflower Eye Drops with Antibiotic-Resistant Gene Regulation Ability for MRSA Keratitis Target Treatment (2023)
- Small
(A1 Refereed original research article in a scientific journal) - Domperidone Inhibits Clostridium botulinum C2 Toxin and Bordetella pertussis Toxin (2023)
- Toxins
(A1 Refereed original research article in a scientific journal) - Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action (2023)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Reference genome for the Northern bat (Eptesicus nilssonii), a most northern bat species (2023)
- Journal of Heredity
(A1 Refereed original research article in a scientific journal) - Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity (2022)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives (2022)
- ACS Infectious Diseases
(A2 Refereed review article in a scientific journal ) - Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin (2021)
- Toxins
(A1 Refereed original research article in a scientific journal) - Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo (2021)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin (2020)
- ACS Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring (2020)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - IGIST - A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling (2020)
- ACS Sensors
(A1 Refereed original research article in a scientific journal) - Single-Peptide TR-FRET Detection Platform for Cysteine-Specific Post-Translational Modifications (2020)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal)