Terhi Heino
University Lecturer, Adjunct professor (Docent) in Cell Biology
terhi.j.heino@utu.fi +358 29 450 4027 +358 50 476 5988 Kiinamyllynkatu 10 Turku Office: C440 ORCID identifier: https://orcid.org/0000-0003-2274-6834 |
biomedicine; regenerative medicine; bone tissue; cell biology; stem cells; osteoporosis; fracture healing; osteogenesis; bone growth; angiogenesis; endothelial cells; wound healing; biomaterials
Terhi Heino is a University Lecturer in the Institute of Biomedicine, Faculty of Medicine, at the University of Turku. In this role, she combines teaching with active research and contributes to curriculum development in medical education. Her scientific interests span stem cells, bone and vascular biology, biomaterials, and translational approaches in regenerative medicine.
She earned her PhD in Cell Biology from the University of Turku in 2005. Following post‑doctoral training at the Pediatric Endocrinology Unit of the Department of Women and Child Health at Karolinska Institutet in Sweden, she returned to the University of Turku in 2008. She was awarded the title of Docent (Adjunct Professor) in Cell Biology in 2013.
Her research focuses on understanding the role of various cell types, including mesenchymal stromal cells (MSCs) in bone and vascular biology. The group is particularly interested in cell–cell and cell–biomaterial interactions and their potential applications in regenerative medicine.
The work relies primarily on in vitro cultures of human bone marrow-derived primary MSCs and peripheral blood–derived cells, complemented by cell lines, various biomaterials, and clinically relevant patient samples.
Overall, the research provides new insights into cellular interactions and key molecular mechanisms regulating angiogenesis and osteogenesis, contributing to the development of improved regenerative approaches for bone and soft tissue healing.
Terhi Heino has extensive experience in university‑level teaching, with over two decades of work in both undergraduate and postgraduate education. Her teaching focuses on histology, cell biology, anatomy, pharmacology, regenerative medicine, and cancer biology. She contributes actively to curriculum planning, implementation, and pedagogical development, supported by her formal pedagogic qualification (60 ECTS, University of Turku). She has served as a mentor in the Biomedicine BSc programme (2013–2022) and has international teaching experience through the Molecular Medicine course at Karolinska Institutet (2013–2018). In addition, she has worked as a partner and mentor in an EU‑funded multidisciplinary entrepreneurial education project (IDEATE, 2013–2016).
- Biomaterial and implant induced ossification: in vitro and in vivo findings (2020)
- Journal of Tissue Engineering and Regenerative Medicine
(A1 Refereed original research article in a scientific journal) - Mesenchymal Stem Cell Therapy for Osteoradionecrosis of the Mandible: a Systematic Review of Preclinical and Human Studies (2020)
- Stem Cell Reviews and Reports
(A2 Refereed review article in a scientific journal ) - Angiogenic potential of human mesenchymal stromal cell and circulating mononuclear cell cocultures is reflected in the expression profiles of proangiogenic factors leading to endothelial cell and pericyte differentiation. (2018)
- Journal of Tissue Engineering and Regenerative Medicine
(A1 Refereed original research article in a scientific journal) - Bone Marrow Niche: Role of Different Cells in Bone Metastasis (2018)
- Current Molecular Biology Reports
(A2 Refereed review article in a scientific journal ) - Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Zoledronic acid in vivo increases in vitro proliferation of rat mesenchymal stromal cells (2016)
- Acta Orthopaedica
(A1 Refereed original research article in a scientific journal) - Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF (2015)
- Orthopaedics and Traumatology: Surgery and Research
(A1 Refereed original research article in a scientific journal) - WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta (2013)
- New England Journal of Medicine
(A1 Refereed original research article in a scientific journal) - Bortezomid is cytotoxic to the human growth plate and permanently impairs bone growth in young mice (2012)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells (2012)
- Journal of Orthopaedic Research
(A1 Refereed original research article in a scientific journal) - Transient 100 nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells (2012)
- Tissue Engineering Part C Methods
(A1 Refereed original research article in a scientific journal) - INTERACTION BETWEEN MARROW-DERIVED HUMAN MESENCHYMAL STEM CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS IN ENDOTHELIAL CELL DIFFERENTIATION (2011)
- Scandinavian Journal of Surgery
(A1 Refereed original research article in a scientific journal) - Intravenous Pamidronate Treatment Improves Growth in Prepubertal Osteogenesis Imperfecta Patients (2011)
- Hormone Research in Paediatrics
(A1 Refereed original research article in a scientific journal) - Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients (2010)
- Journal of Orthopaedic Research
(A1 Refereed original research article in a scientific journal) - Evidence for the role of osteocytes in the initiation of targeted remodeling (2009)
- Technology and Health Care
(A1 Refereed original research article in a scientific journal) - Microdamage detection and repair in bone: fracture mechanics, histology, cell biology (2009)
- Technology and Health Care
(A1 Refereed original research article in a scientific journal) - Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading (2009)
- BONE
(A1 Refereed original research article in a scientific journal) - Differentiation of osteoblasts and osteocytes from mesenchymal stem cells (2008)
- Current Stem Cell Research and Therapy
(A2 Refereed review article in a scientific journal ) - Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation (2008)
- BONE
(A1 Refereed original research article in a scientific journal) - Tamoxifen impairs both longitudinal and cortical bone growth in young male rats (2008)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal)



