Leena Kainulainen
 


leena.kainulainen@utu.fi








Areas of expertise
paediatrics; immunodeficiency; paediatric infectious diseases; respiratory infections; rhinovirus

Biography



Docent
Leena Kainulainen graduated from medical school in 1995(University of Turku)
and defended her PhD theses on CVID in 2000. She received specialist licence in
paediatrics in 2005 and in pediatric infectious diseases 2013 and was appointed
as a docent in paediatrics in 2013 (University of Turku). She is currently
working as Head of the Division of Pediatric Care in Turku University Hospital
and as an immunology consultant at Department of Pediatrics and Medicine at
Turku University Hospital. She participates in neonatal screening for
severe immunodeficiencies.






Research



Docent
Kainulainen´s research is  focused on
primary immunodeficiency. Her current research interests comprise rhinovirus
infections in primary hypogammaglobulinemia patients. Clinical trial on the
treatment of rhinovirus infection with pegylated interferon alfa in CVID
patients is ongoing. Research project on innate immunity in autoimmune patients
is ongoing. In addition, she participates in research project aiming at  evaluating immunological status in pediatric
patients with neonatal cardiac surgery.






Teaching



Docent
Kainulainen has been working as a clinical lecturer in pediatrics 2004 and
2006. Currently she teaches regularly medical students and paediatric residents
as a part of her clinical duties.






Publications
  
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  • T cell immunity following COVID-19 vaccination in adult patients with primary antibody deficiency - a 22-month follow-up  (2023)  
    • Frontiers in immunology
     Hurme Antti, Jalkanen Pinja, Marttila-Vaara Minna, Heroum Jemna, Jokinen Heidi, Vara Saimi, Liedes Oona, Lempainen Johanna, Melin Merit, Julkunen Ilkka, Kainulainen Leena
    (
    A1 Refereed original research article in a scientific journal)


  • Low pre-vaccination SARS-CoV-2 seroprevalence in Finnish health care workers: a prospective cohort study  (2022)  
    • Infectious Diseases
     Tähtinen Paula A, Ivaska Lauri, Jalkanen Pinja, Kakkola Laura, Kainulainen Leena, Hytönen Jukka, Vuorinen Tytti, Waris Matti, Peltola Ville, Oksi Jarmo, Julkunen Ilkka, Lempainen Johanna
    (
    A1 Refereed original research article in a scientific journal)


  • STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation  (2022)  
    • Immunity
     Masle-Farquhar Etienne, Jackson Katherine JL, Peters Timothy J, Al-Eryani Ghamdan, Singh Mandeep, Payne Kathryn J, Rao Geetha, Avery Danielle T, Apps Gabrielle, Kingham Jennifer, Jara Christopher J, Skvortsova Ksenia, Swarbrick Alexander, Ma Cindy S, Suan Daniel, Uzel Gulbu, Chua Ignatius, Leiding Jennifer W, Heiskanen Kaarina, Preece Kahn, Kainulainen Leena, O'Sullivan Michael, Cooper Megan A, Seppänen Mikko RJ, Mustjoki Satu, Brothers Shannon, Vogel Tiphanie P, Brink Robert, Tangye Stuart G, Reed Joanne H, Goodnow Christopher C
    (
    A1 Refereed original research article in a scientific journal)


  • Clinical, functional and genetic characterization of 16 patients suffering from chronic granulomatous disease variants - identification of 11 novel mutations in CYBB  (2021)  
    • Clinical and Experimental Immunology
     Mollin M, Beaumel S, Vigne B, Brault J, Roux-Buisson N, Rendu J, Barlogis V, Catho G, Dumeril C, Fouyssac F, Monnier D, Gandemer V, Revest M, Brion JP, Bost-Bru C, Jeziorski E, Eitenschenck L, Jarrasse C, Haus SD, Houachee-Chardin M, Hancart M, Michel G, Bertrand Y, Plantaz D, Kelecic J, Traberg R, Kainulainen L, Faure J, Fieschi F, Stasia MJ
    (
    A1 Refereed original research article in a scientific journal)


  • Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child  (2021)  
    • Nature Medicine
     Ogishi Masato, Yang Rui, Aytekin Caner, Langlais David, Bourgey Mathieu, Khan Taushif, Al Ali Fatima, Rahman Mahbuba, Delmonte Ottavia M., Chrabieh Maya, Zhang Peng, Gruber Conor, Pelham Simon J., Spaan András N., Rosain Jérémie, Lei Wei-Te, Drutman Scott, Hellmann Matthew D., Callahan Margaret K., Adamow Matthew, Wong Phillip, Wolchok Jedd D., Rao Geetha, Ma Cindy S., Nakajima Yuka, Yaguchi Tomonori, Chamoto Kenji, Williams Samuel C., Emile Jean-Francois, Rozenberg Flore, Glickman Michael S., Rapaport Franck, Kerner Gaspard, Allington Garrett, Tezcan Ilhan, Cagdas Deniz, Hosnut Ferda O., Dogu Figen, Ikinciogullari Aydan, Rao V. Koneti, Kainulainen Leena, Béziat Vivien, Bustamante Jacinta, Vilarinho Silvia, Lifton Richard P., Boisson Bertrand, Abel Laurent, Bogunovic Dusan, Marr Nico, Notarangelo Luigi D., Tangye Stuart G., Honjo Tasuku, Gros Philippe, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
    (
    A1 Refereed original research article in a scientific journal)


  • Multibatch Cytometry Data Integration for Optimal Immunophenotyping  (2021)  
    • Journal of Immunology
     Ogishi Masato, Yang Rui, Gruber Conor, Zhang Peng, Pelham Simon J, Spaan András N, Rosain Jérémie, Chbihi Marwa, Han Ji Eun, Rao V Koneti, Kainulainen Leena, Bustamante Jacinta, Boisson Bertrand, Bogunovic Dusan, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
    (
    A1 Refereed original research article in a scientific journal)


  • Increased antiviral response in circulating lymphocytes from hypogammaglobulinemia patients  (2020)  
    • Allergy
     Wirz Oliver F., Üzülmez Öykü, Jansen Kirstin, van de Veen Willem, Lammela Auli, Kainulainen Leena, Vuorinen Tytti, Breiteneder Heimo, Akdis Cezmi A., Jartti Tuomas, Akdis Mübeccel
    (
    A1 Refereed original research article in a scientific journal)


  • The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia  (2020)  
    • Frontiers in immunology
     Vakkilainen S, Kleino I, Honkanen J, Salo H, Kainulainen L, Grasbeck M, Kekalainen E, Makitie O, Klemetti P
    (
    A1 Refereed original research article in a scientific journal)


  • Tavallinen infektiokierre  (2019)  Lasten infektiosairaudet Ville Peltola, Leena Kainulainen
    (
    D2 Article in a professional compilation book)


  • Suomi on synnynnäisten immuunivajeiden maa  (2018)  
    • Duodecim
     Taskinen M, Kainulainen L, Heiskanen K, Kainulainen L, Renko M, Heiskanen-Kosma T, Tapiainen T, Vettenranta K, Lukkarinen H, Heikinheimo M, Seppänen M
    (
    D1 Article in a professional journal)



Last updated on 12/07/2023 12:37:42 PM