Leena Kainulainen
Areas of expertise
paediatrics; immunodeficiency; paediatric infectious diseases; respiratory infections; rhinovirus
Biography
Docent
Leena Kainulainen graduated from medical school in 1995(University of Turku)
and defended her PhD theses on CVID in 2000. She received specialist licence in
paediatrics in 2005 and in pediatric infectious diseases 2013 and was appointed
as a docent in paediatrics in 2013 (University of Turku). She is currently
working as Head of the Division of Pediatric Care in Turku University Hospital
and as an immunology consultant at Department of Pediatrics and Medicine at
Turku University Hospital. She participates in neonatal screening for
severe immunodeficiencies.
Research
Docent
Kainulainen´s research is focused on
primary immunodeficiency. Her current research interests comprise rhinovirus
infections in primary hypogammaglobulinemia patients. Clinical trial on the
treatment of rhinovirus infection with pegylated interferon alfa in CVID
patients is ongoing. Research project on innate immunity in autoimmune patients
is ongoing. In addition, she participates in research project aiming at evaluating immunological status in pediatric
patients with neonatal cardiac surgery.
Teaching
Docent
Kainulainen has been working as a clinical lecturer in pediatrics 2004 and
2006. Currently she teaches regularly medical students and paediatric residents
as a part of her clinical duties.
Publications
- 22q11.2-deleetio-oireyhtymän hoito ja seuranta (2025) Wahrmann Sakari, Strang-Karlsson Sonja, Rajala Katri, Koillinen Hannele, Komulainen-Ebrahim Jonna, Räsänen Sami, Körkkö Jarmo, Lindholm Päivi, Ansamaa Terhi, Keski-Filppula Riikka, Lempainen Johanna, Kainulainen Leena, Wedenoja Satu, Repo Johanna, Kuismin Outi
(A2 Refereed review article in a scientific journal )
- Finnish nationwide controlled register study found increased inpatient infections in children with 22q11.2 deletion syndrome (2024) Wahrmann, Sakari; Kainulainen, Leena; Lempainen, Johanna; Kytö, Ville
(A1 Refereed original research article in a scientific journal)
- Genetic polymorphisms of TLR1, TLR2, TLR3 and TLR4 in patients with recurrent or severe infections (2024)
- International Journal of Immunogenetics
Teräsjärvi Johanna, Kainulainen Leena, Peltola Ville, Mertsola Jussi, Hakanen Antti, He Qiushui
(A1 Refereed original research article in a scientific journal)
- Primaariset immuunivajavuustilat (2024) Mikrobiologia, immunologia ja infektiosairaudet. Kirja 2, Immunologia Kainulainen, Leena; Seppänen, Mikko
(D2 Article in a professional compilation book)
- Shorter birth length and decreased T-cell production and function predict severe infections in children with non-severe combined immunodeficiency cartilage-hair hypoplasia (2024)
- Journal of Allergy and Clinical Immunology: Global
Pello Eetu, Kainulainen Leena, Vakkilainen Mikko, Klemetti Paula, Taskinen Mervi, Mäkitie Outi, Vakkilainen Svetlana
(A1 Refereed original research article in a scientific journal)
- Wiskott-Aldrich Syndrome: A study on 577 patients defining the genotype as a predictive biomarker for disease severity (2024) Vallée Tanja C, Glasmacher Jannik S, Buchner Hannes, Arkwright Peter D, Behrends Uta, Bondarenko Anastasia, Browning Michael J, Buchbinder David K, Cattoni Alessandro, Chernyshova Liudmyla, Ciznar Peter, Cole Theresa, Czogala Wojciech, Dueckers Gregor, Edgar John David M, Erbey Fatih, Fasth Anders, Ferrua Francesca, Formankova Renata, Gambineri Eleonora, Gennery Andrew R, Goldman Frederick D, Gonzalez-Granado Luis Ignacio, Heilmann Carsten, Heiskanen-Kosma Tarja, Juntti Hanna, Kainulainen Leena, Kanegane Hirokazu, Karaca Neslihan E., Sebnem Kilic Sara, Klein Christoph, Koltan Sylwia MD PhD, Kondratenko Irina, Meyts Isabelle, Nasrullayeva Gulnara M, Notarangelo Lucia Dora, Pasic Srdjan, Pellier Isabelle, Pignata Claudio, Misbah Siraj Ahmed, Schulz Ansgar S, Segundo Gesmar RS, Shcherbina Anna, Slatter Mary A, Sokolic Robert, Soler-Palacin Pere, Stepensky Polina, van Montfrans Joris M., Ryhänen Samppa, Wolska-Kuśnierz Beata MD PhD, Ziegler John B, Zhao Xiaodong, Aiuti Alessandro, Ochs Hans D, Albert Michael H
(A1 Refereed original research article in a scientific journal)
- Childhood manifestations of 22q11.2 deletion syndrome: A Finnish nationwide register-based cohort study (2023) Wahrmann Sakari, Kainulainen Leena, Kytö Ville, Lempainen Johanna
(A1 Refereed original research article in a scientific journal)
- Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome (2023)
- Journal of Allergy and Clinical Immunology
Leiding Jennifer W, Vogel Tiphanie P, Santarlas Valentine GJ, Mhaskar Rahul, Smith Madison R, Carisey Alexandre, Vargas-Hernández Alexander, Silva-Carmona Manuel, Heeg Maximilian, Rensing-Ehl Anne, Neven Bénédicte, Hadjadj Jérôme, Hambleton Sophie, Ronan Leahy Timothy, Meesilpavikai Kornvalee, Cunningham-Rundles Charlotte, Dutmer Cullen M, Sharapova Svetlana O, Taskinen Mervi, Chua Ignatius, Hague Rosie, Klemann Christian, Kostyuchenko Larysa, Morio Tomohiro, Thatayatikom Akaluck, Ozen Ahmet, Scherbina Anna, Bauer Cindy S, Flanagan Sarah E, Gambineri Eleonora, Giovannini-Chami Lisa, Heimall Jennifer, Sullivan Kathleen E, Allenspach Eric, Romberg Neil, Deane Sean G, Prince Benjamin T, Rose Melissa J, Bohnsack John, Mousallem Talal, Jesudas Rohit, Santos Vilela Maria Marluce Dos, O'Sullivan Michael, Pachlopnik Schmid Jana, Průhová Štěpánka, Klocperk Adam, Rees Matthew, Su Helen, Bahna Sami, Baris Safa, Bartnikas Lisa M, Chang Berger Amy, Briggs Tracy A, Brothers Shannon, Bundy Vanessa, Chan Alice Y, Chandrakasan Shanmuganathan, Christiansen Mette, Cole Theresa, Cook Matthew C, Desai Mukesh M, Fischer Ute, Fulcher David A, Gallo Silvanna, Gauthier Amelie, Gennery Andrew R, Gonçalo Marques José, Gottrand Frédéric, Grimbacher Bodo, Grunebaum Eyal, Haapaniemi Emma, Hämäläinen Sari, Heiskanen Kaarina, Heiskanen-Kosma Tarja, Hoffman Hal M, Gonzalez-Granado Luis Ignacio, Guerrerio Anthony L, Kainulainen Leena, Kumar Ashish, Lawrence Monica G, Levin Carina, Martelius Timi, Neth Olaf, Olbrich Peter, Palma Alejandro, Patel Niraj C, Pozos Tamara, Preece Kahn, Lugo Reyes Saúl Oswaldo, Russell Mark A, Schejter Yael, Seroogy Christine, Sinclair Jan, Skevofilax Effie, Suan Daniel, Suegeorgz Daniel, Szabolcs Paul, Velasco Helena, Warnatz Klaus, Walkovich Kelly, Worth Austen; STAT3 GOF Working Group members, Seppänen Mikko RJ, Torgerson Troy R, Sogkas Georgios, Ehl Stephan, Tangye Stuart G, Cooper Megan A, Milner Joshua D, Forbes Satter Lisa R
(A1 Refereed original research article in a scientific journal)
- Overlap between EEC and AEC syndrome and immunodeficiency in a preterm infant with a TP63 variant (2023)
- European Journal of Medical Genetics
Helenius Kjell, Ojala Liisa, Kainulainen Leena, Peltonen Sirkku, Hietala Marja, Pohjola Pia, Parikka Vilhelmiina
(A1 Refereed original research article in a scientific journal)
- Tavallisimmat primaarit immuunipuutokset (2023) Lastentaudit Helminen Merja, Kainulainen Leena
(D2 Article in a professional compilation book)
- T cell immunity following COVID-19 vaccination in adult patients with primary antibody deficiency - a 22-month follow-up (2023) Hurme Antti, Jalkanen Pinja, Marttila-Vaara Minna, Heroum Jemna, Jokinen Heidi, Vara Saimi, Liedes Oona, Lempainen Johanna, Melin Merit, Julkunen Ilkka, Kainulainen Leena
(A1 Refereed original research article in a scientific journal)
- Low pre-vaccination SARS-CoV-2 seroprevalence in Finnish health care workers: a prospective cohort study (2022) Tähtinen Paula A, Ivaska Lauri, Jalkanen Pinja, Kakkola Laura, Kainulainen Leena, Hytönen Jukka, Vuorinen Tytti, Waris Matti, Peltola Ville, Oksi Jarmo, Julkunen Ilkka, Lempainen Johanna
(A1 Refereed original research article in a scientific journal)
- STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation (2022) Masle-Farquhar Etienne, Jackson Katherine JL, Peters Timothy J, Al-Eryani Ghamdan, Singh Mandeep, Payne Kathryn J, Rao Geetha, Avery Danielle T, Apps Gabrielle, Kingham Jennifer, Jara Christopher J, Skvortsova Ksenia, Swarbrick Alexander, Ma Cindy S, Suan Daniel, Uzel Gulbu, Chua Ignatius, Leiding Jennifer W, Heiskanen Kaarina, Preece Kahn, Kainulainen Leena, O'Sullivan Michael, Cooper Megan A, Seppänen Mikko RJ, Mustjoki Satu, Brothers Shannon, Vogel Tiphanie P, Brink Robert, Tangye Stuart G, Reed Joanne H, Goodnow Christopher C
(A1 Refereed original research article in a scientific journal)
- Clinical, functional and genetic characterization of 16 patients suffering from chronic granulomatous disease variants - identification of 11 novel mutations in CYBB (2021)
- Clinical and Experimental Immunology
Mollin M, Beaumel S, Vigne B, Brault J, Roux-Buisson N, Rendu J, Barlogis V, Catho G, Dumeril C, Fouyssac F, Monnier D, Gandemer V, Revest M, Brion JP, Bost-Bru C, Jeziorski E, Eitenschenck L, Jarrasse C, Haus SD, Houachee-Chardin M, Hancart M, Michel G, Bertrand Y, Plantaz D, Kelecic J, Traberg R, Kainulainen L, Faure J, Fieschi F, Stasia MJ
(A1 Refereed original research article in a scientific journal)
- Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child (2021) Ogishi Masato, Yang Rui, Aytekin Caner, Langlais David, Bourgey Mathieu, Khan Taushif, Al Ali Fatima, Rahman Mahbuba, Delmonte Ottavia M., Chrabieh Maya, Zhang Peng, Gruber Conor, Pelham Simon J., Spaan András N., Rosain Jérémie, Lei Wei-Te, Drutman Scott, Hellmann Matthew D., Callahan Margaret K., Adamow Matthew, Wong Phillip, Wolchok Jedd D., Rao Geetha, Ma Cindy S., Nakajima Yuka, Yaguchi Tomonori, Chamoto Kenji, Williams Samuel C., Emile Jean-Francois, Rozenberg Flore, Glickman Michael S., Rapaport Franck, Kerner Gaspard, Allington Garrett, Tezcan Ilhan, Cagdas Deniz, Hosnut Ferda O., Dogu Figen, Ikinciogullari Aydan, Rao V. Koneti, Kainulainen Leena, Béziat Vivien, Bustamante Jacinta, Vilarinho Silvia, Lifton Richard P., Boisson Bertrand, Abel Laurent, Bogunovic Dusan, Marr Nico, Notarangelo Luigi D., Tangye Stuart G., Honjo Tasuku, Gros Philippe, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(A1 Refereed original research article in a scientific journal)
- Multibatch Cytometry Data Integration for Optimal Immunophenotyping (2021) Ogishi Masato, Yang Rui, Gruber Conor, Zhang Peng, Pelham Simon J, Spaan András N, Rosain Jérémie, Chbihi Marwa, Han Ji Eun, Rao V Koneti, Kainulainen Leena, Bustamante Jacinta, Boisson Bertrand, Bogunovic Dusan, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(A1 Refereed original research article in a scientific journal)
- Increased antiviral response in circulating lymphocytes from hypogammaglobulinemia patients (2020) Wirz Oliver F., Üzülmez Öykü, Jansen Kirstin, van de Veen Willem, Lammela Auli, Kainulainen Leena, Vuorinen Tytti, Breiteneder Heimo, Akdis Cezmi A., Jartti Tuomas, Akdis Mübeccel
(A1 Refereed original research article in a scientific journal)
- The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia (2020) Vakkilainen S, Kleino I, Honkanen J, Salo H, Kainulainen L, Grasbeck M, Kekalainen E, Makitie O, Klemetti P
(A1 Refereed original research article in a scientific journal)
- Tavallinen infektiokierre (2019) Lasten infektiosairaudet Ville Peltola, Leena Kainulainen
(D2 Article in a professional compilation book)
- Suomi on synnynnäisten immuunivajeiden maa (2018) Taskinen M, Kainulainen L, Heiskanen K, Kainulainen L, Renko M, Heiskanen-Kosma T, Tapiainen T, Vettenranta K, Lukkarinen H, Heikinheimo M, Seppänen M
(D1 Article in a professional journal)
