Niina Saarinen-Aaltonen

- Docent,
Department of Life Technologies (Faculty of Technology)

niina.saarinen@utu.fi

Itäinen Pitkäkatu 4

Turku

Publications

1 of 2

Serum Hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein a but does not serve as an independent marker for preeclampsiaTranscriptional response networks for elucidating mechanisms of action of multitargeted agents (2024)
- Biology of Reproduction
Heinosalo, Taija; Saarinen, Niina; Biehl, Alexander; Rytkönen, Kalle T; Villa, Pia M; Juhila, Juuso; Koskimies, Pasi; Laiho, Asta; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Elo, Laura L; Laivuori, Hannele; Poutanen, Matti
(A1 Refereed original research article in a scientific journal)
Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)
- International Journal of Molecular Sciences
Heinosalo Taija, Rytkönen Kalle T., Saarinen Niina, Järvensivu Päivi, Damdimopoulou Pauliina, Strauss Leena, Orasniemi Satu, Horshauge Petricia, Gabriel Michael, Koskimies Pasi, Ohlsson Claes, Kronqvist Pauliina, Poutanen Matti
(A1 Refereed original research article in a scientific journal)
CC chemokine ligand 2 (CCL2) stimulates aromatase gene expression in mammary adipose tissue (2021)
- FASEB Journal
Martínez-Chacón Gabriela, Yatkin Emrah, Polari Lauri, Dinç Deniz D, Peuhu Emilia, Hartiala Pauliina, Saarinen Niina, Mäkelä Sari
(A1 Refereed original research article in a scientific journal)
Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model (2021)
- Cancer Letters
Xanthoulea Sofia, Konings Gonda F. J., Saarinen Niina, Delvoux Bert, Kooreman Loes F. S., Koskimies Pasi, Häkkinen Merja R., Auriola Seppo, D’Avanzo Elisabetta, Walid Youssef, Verhaegen Frank, Lieuwes Natasja G., Caiment Florian, Kruitwagen Roy, Romano Andrea; ENITEC
(A1 Refereed original research article in a scientific journal)
Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseasesLihavuuden vaikutus estrogeenisignalointiin ja rintasyöpäriskiin (2019)
- Molecular and Cellular EndocrinologyLääkärilehti
Heinosalo T., Saarinen N., Poutanen M.
(A2 Refereed review article in a scientific journal )
Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue (2018)
- Journal of Pharmaceutical and Biomedical Analysis
Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S
(A1 Refereed original research article in a scientific journal)
Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure (2018)
- International Journal of Molecular SciencesCancer Research
Konings GF, Saarinen N, Delvoux B, Kooreman L, Koskimies P, Krakstad C, Fasmer KE, Haldorsen IS, Zaffagnini A, Häkkinen MR, Auriola S, Dubois L, Lieuwes N, Verhaegen F, Schyns LE, Kruitwagen RF; ENITEC Consortium, Xanthoulea S, Romano A.
(A1 Refereed original research article in a scientific journal)
HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium (2018)
- Endocrine-Related Cancer
Päivi Järvensivu, Taija Heinosalo, Janne Hakkarainen, Pauliina Kronqvist, Niina Saarinen, Matti Poutanen
(A1 Refereed original research article in a scientific journal)
IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissueImproved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo (2018)
- FASEB JournalClinical Cancer Research
Gabriela Martínez-Chacón, Kristy A. Brown, Maria M. Docanto, Himanshu Kumar, Seppo Salminen, Niina Saarinen, Sari Mäkelä
(A1 Refereed original research article in a scientific journal)
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice (2017)
- American Journal of Physiology : Endocrinology and Metabolism
Ohlsson C, Hammarstedt A, Vandenput L, Saarinen N, Ryberg H, Windahl SH, Farman HH, Jansson JO, Moverare-Skrtic S, Smith U, Zhang FP, Poutanen M, Hedjazifar S, Sjogren K
(A1 Refereed original research article in a scientific journal)
2016
- Drug Discovery Today
Kibble M, Khan SA, Saarinen N, Iorio F, Saez-Rodriguez J, Mäkelä S, Aittokallio T
(A2 Refereed review article in a scientific journal )
HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo (2015)
- Chemico-Biological Interactions
Jarvensivu P, Saloniemi-Heinonen T, Awosanya M, Koskimies P, Saarinen N, Poutanen M
(A1 Refereed original research article in a scientific journal)
Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products (2015)
- Natural Product Reports
Kibble M, Saarinen N, Tang J, Wennerberg K, Mäkelä S, Aittokallio T
(A2 Refereed review article in a scientific journal )
Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity (2015)
- Molecular and Cellular Endocrinology
Polari L., Yatkin E., Martínez Chacón M., Ahotupa M., Smeds A., Strauss L., Zhang F., Poutanen M., Saarinen N., Mäkelä S.
(A1 Refereed original research article in a scientific journal)
2014
Saarinen Niina, Mäkelä Sari
(A2 Refereed review article in a scientific journal )
Novel Lignan and Stilbenoid Mixture Shows Anticarcinogenic Efficacy in Preclinical PC-3M-luc2 Prostate Cancer Model (2014)
- PLoS ONE
Yatkin E, Polari L, Laajala TD, Smeds A, Eckerman C, Holmbom B, Saarinen N, Aittokallio T, Mäkelä S.
(A1 Refereed original research article in a scientific journal)
A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo.2013
Järvensivu P, Strauss L, Mäkelä S, Poutanen M, Saarinen N
(Other publication)
Estradiol, tamoxifen, and flaxseed alter IL-1β and IL-1Ra levels in normal human breast tissue in vivo. (2012)
- Journal of Clinical Endocrinology and Metabolism
Abrahamsson A, Morad V, Saarinen NM, Dabrosin C
(A1 Refereed original research article in a scientific journal)
2012
Laajala TD, Corander J, Saarinen NM, Makela K, Savolainen S, Suominen MI, Alhoniemi E, Makela S, Poutanen M, Aittokallio T
(A1 Refereed original research article in a scientific journal)
Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo. (2011)
- PLoS ONE
Åberg UW, Saarinen N, Abrahamsson A, Nurmi T, Engblom S, Dabrosin C
(A1 Refereed original research article in a scientific journal)