Seija Grenman
Professor, emerita MD PhD
Department of Obstetrics and Gynecology seigre@utu.fi +358 40 733 6312 Kiinamyllynkatu 4-8 Turku |
Gynekologinen syöpä, HPV-tutkimus
Professor Seija Grenman has a long history in
promoting women’s health issues both nationally and internationally. At the
national level, she has served as the President of the Finnish Cancer
Foundation 2010-2016 and the president of the Finnish Gynecological
Association 2015 - 2017. Professor
Grenman has also been an active member of the Nordic Society of Obstetrics and
Gynecology (NFOG), first serving as the Chairman of the Scientific Committee
and then as the Chairman of NFOG in 2006-2010. Since 2009 she has been a FIGO
Executive Board Member representing Finland as Vice President in 2015-2018. She
is an ex officio member of the FIGO Committees on Gynecologic Oncology and
Women´s Health and Human Rights (WHHR) as well as the Working Group on Violence
against Women. Her main interests in research are Ovarian Cancer and HPV. She
is the principal investigator at Turku University Hospital in two consortiums
studying ovarian cancer : a national OVCURE-consortium funded by the Finnish
Academy and an EU-funded HERCULES
consortium. Since 1998 she has collaborated with professor Stina Syrjänen on
the Finnish Family HPV Study including 300 families and newborn babies.
Personalized therapy of Ovarian cancer
Ovarian
cancer research was started as a consortium at the University of Turku in 2009,
but has expanded in 2015 to a consortium supported by the Academy of Finland
and in 2016 to an EU-consortium consisting of
8 research groups in Finland, Sweden, France and Italy. The main
objectives of the study are to comprehensively characterize high-grade serous
ovarian cancer ( HGS-OvCa) by intergrating and modelling clinical and
biological data (e.g. genetics, transcriptomics, protein binding, drug
screening) from primary, metastatic and relapsed tumors from various anatomical
sites of HGS-OvCa patients, and to establish combinatorial treatment modalities
that effectively kill HGS-OvCa tumor cell subpopulations. The projects have
been supported by the Academy of Finland, Finnish Cancer Foundation, EU-grant
and the Government Special Foundation to Turku University Hospital.
The Finnish Family HPV Study
The Finnish
Family HPV study is a prospective cohort study conducted at the University of
Turku, Turku Finland. A total of 329 mother, 131 fathers and 331 new born
babies have been recruited to this study between 1998-2002 and the participants
have been followed up since then. The purpose of the study has been to evaluate
the transmission of HPV infection and to identify special risk groups for
persistent HPV infection among family members. Currently the work is focusing
on the effects of HPV-specific immunity on the outcome of HPV infections in
women and in early childhood.
Seija Grénman has experience on teaching for a number of years as a clinical teacher until 2010 and as a professor there after. She was nominated as the teacher of the year by medical students in 2001.
- Genotype-Specific Incidence and Clearance of Human Papillomavirus in Oral Mucosa of Women – A Six-Year Follow-Up Study (2013)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Gynekologiset syövät (2013) Syöpätaudit Grénman Seija, Arto Leminen
(D2 Artikkeli ammatillisessa kokoomateoksessa) - Identifying prognostically relevant subsets of endometrial cancer using unsupervised clustering of immunohistochemical staining data (2013)
- Virchows Archiv
(O2 Muu julkaisu ) - Is perioperative visual estimation of intra-abdominal tumor spread reliable in ovarian cancer surgery after neoadjuvant chemotherapy? (2013)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma. (2013)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quality of life and costs of levonorgestrel-releasing intrauterine system or hysterectomy in the treatment of menorrhagia – a 10-year randomized controlled trial (2013)
- American Journal of Obstetrics and Gynecology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reply to Kathleen D'Hauwers, Gunter De Win and Wiebren Tjalma's Letter to the Editor re: Katja Kero, Jaana Rautava, Kari Syrjanen, Seija Grenman, Stina Syrjanen. Oral Mucosa as a Reservoir of Human Papillomavirus: Point Prevalence, Genotype Distribution, and Incident Infections Among Males in a 7-year Prospective Study. Eur Urol 2012;62:1063-70 (2013)
- European Urology
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - FDG PET/CT in staging of advanced epithelial ovarian cancer: Frequency of supradiaphragmatic lymph node metastasis challenges the traditional pattern of disease spread (2012)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - High-risk human papillomavirus associated with incident cervical intraepithelial neoplasia developing in mothers in the Finnish Family HPV Study cohort (2012)
- Scandinavian Journal of Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human papillomavirus genotypes present in the oral mucosa of newborns and their concordance with maternal cervical human papillomavirus genotypes (2012)
- Journal of Pediatrics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reply from Authors re: Guido Barbagli, Salvatore Sansalone, Massimo Lazzeri. Oral Mucosa and Urethroplasty: It's Time to Change. Eur Urol 2012;62:1071-3 (2012)
- European Urology
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Kohdun limakalvon ja kohtulihaksen kasvaimet (2011) Naistentaudit ja synnytykset Grenman S, Auranen A
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Serum HE4 profile during primary chemotherapy of epithelial ovarian cancer (2011)
- International Journal of Gynecological Cancer
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The effect of hysterectomy or levonorgestrel-releasing intrauterine system on cardiovascular disease risk factors in menorrhagia patients: A 10-year follow-up of a randomised trial (2011)
- Maturitas
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genotype-specific clearance of genital human papillomavirus (HPV) infections among mothers in the finnish family HPV study (2010)
- Journal of Clinical Microbiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genotype-specific persistence of genital human papillomavirus (HPV) infections in women followed for 6 years in the finnish family HPV study (2010)
- Journal of Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Per Bergsjö, in memoriam (2010)
- Acta Obstetricia et Gynecologica Scandinavica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Promoting female reproductive and sexual health: The importance of attitude (2010)
- International Journal of Gynecology and Obstetrics
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Promoting female reproductive and sexual health: The importance of attitude. Editorial (2010)
- International Journal of Gynecology and Obstetrics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Scandinavian spirit and important decisions at the NFOG 2010 congress: more support available for research and improving clinical skills (2010)
- Acta Obstetricia et Gynecologica Scandinavica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )