Ph.D., adj. prof. Janne Leivo - UTU Research Portal

Janne Leivo
Ph.D., adj. prof.

- Senior Research Fellow,
Biotechnology (Department of Life Technologies)
- Docent,
Department of Life Technologies (Faculty of Technology)
- ,
InFLAMES Flagship (Faculty of Medicine)

jpleiv@utu.fi

Kiinamyllynkatu 10

Turku

: D6048

: https://orcid.org/0000-0002-1032-6667(external)

Lab website(external)

Turku Prostate Cancer Consortium(external)

FICan West Cancer Research Laboratory(external)

Antibody engineering; Immunoassays; Extracellular vesicles; Exosomes; Prostate cancer

MSCA-ITN proEVLifecycle (https://proevlifecycle.eu/)

The primary focus of our group is to design and validate novel biomarker concepts for early cancer detection and precision disease management. We have established a biomarker development pipeline based on glycovariants of various tumor markers and extracellular vesicles.

Our research is in the interface of basic and translational research, combining biomarker discovery, antibody and assay development and clinical validation to address the clinical need for the detection of most common solid cancers.

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Development of anti-immunocomplex specific antibodies and non-competitive time-resolved fluorescence immunoassay for the detection of estradiol (2019)
- Analytical and Bioanalytical Chemistry
Leivo J., Kivimäki L., Juntunen E., Pettersson K., Lamminmäki U.
Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin (2019)
- Biosensors
Sultana Akter, Teemu Kustila, Janne Leivo, Gangatharan Muralitharan, Markus Vehniäinen, Urpo Lamminmäki
Accelerating food safety and quality control: The use of antibody engineering techniques in the detec-tion of low-molecular weight food contaminants (2016) Leivo Janne
Development of recombinant antibody-based enzyme-linked immunosorbent assay (ELISA) for the detection of skatole (2016)
- Analytical Biochemistry
Janne Leivo, Joonas Mäkela, Jaana Rosenberg, Urpo Lamminmäki
Role of lectin microarrays in cancer diagnosis (2016)
- Proteomics
Parvez Syed, Kamlesh Gidwani, Henna Kekki, Janne Leivo, Kim Pettersson, Urpo Lamminmäki
Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer (2015)
- International Journal of Cancer
Diederick Duijvesz, C. Yin L. Versluis,†, Christa A.M. van der Fels, Mirella S. Vredenbregt-van den Berg, Janne Leivo, Mari T. Peltola, Chris H. Bangma, Kim S.I. Pettersson, Guido Jenster
Multiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
- Journal of Agricultural and Food Chemistry
Leivo J, Lamminmäki U, Lövgren T, Vehniäinen M
Directed antibody-engineering techniques and their applications in food immunoassays (2011)
- Trends in Analytical Chemistry
Markus V, Janne L, Urpo L
Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously (2011)
- Analytical Biochemistry
Leivo J, Chappuis C, Lamminmaki U, Lovgren T, Vehniainen M
Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
- Protein Engineering, Design and Selection
Brockmann EC, Akter S, Savukoski T, Huovinen T, Lehmusvuori A, Leivo J, Saavalainen O, Azhayev A, Lovgren T, Hellman J, Lamminmaki U