Janne Leivo
Ph.D.
jpleiv@utu.fi Kiinamyllynkatu 10 Turku : D6048 |
Antibody engineering; Immunoassays; Extracellular vesicles; Diagnostics
I am a senior researcher fellow and InFLAMES Group leader at the Department of Life Technologies and FICAN West Cancer Centre. My group bridges novel biomarker concepts, extracellular vesicle analytics, and advanced immunoassay technologies to enable more sensitive and specific diagnostics.
The primary focus of our group is to design and validate novel biomarker concepts for early cancer detection and precision disease management. We have established a biomarker development pipeline based on glycovariants of various tumor markers and extracellular vesicles.
Our research is in the interface of basic and translational research, combining biomarker discovery, antibody and assay development, and clinical validation to address the clinical need for the detection of the most common solid cancers.
- A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles (2019)
- Scientific Reports
- Detection of Food Taints and Contaminants Using Novel Engineered Antibodies (2019) Rapid Antibody-based Technologies in Food Analysis Leivo J., Lamminmäki U.
- Development of anti-immunocomplex specific antibodies and non-competitive time-resolved fluorescence immunoassay for the detection of estradiol (2019)
- Analytical and Bioanalytical Chemistry
- Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin (2019)
- Biosensors
- Accelerating food safety and quality control: The use of antibody engineering techniques in the detec-tion of low-molecular weight food contaminants (2016) Leivo Janne
- Development of recombinant antibody-based enzyme-linked immunosorbent assay (ELISA) for the detection of skatole (2016)
- Analytical Biochemistry
- Role of lectin microarrays in cancer diagnosis (2016)
- Proteomics
- Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer (2015)
- International Journal of Cancer
- Multiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
- Journal of Agricultural and Food Chemistry
- Directed antibody-engineering techniques and their applications in food immunoassays (2011)
- Trends in Analytical Chemistry
- Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously (2011)
- Analytical Biochemistry
- Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
- Protein Engineering, Design and Selection
- Development of an optical surface plasmon resonance biosensor assay for (fluoro)quinolones in egg, fish, and poultry meat (2008)
- Analytica Chimica Acta
