Professor of Preclinical Imaging and Drug Research Anne Roivainen - UTU Research Portal

Anne Roivainen
Professor of Preclinical Imaging and Drug Research

- Professor,
Turku PET Centre (Independent units)

aroivan@utu.fi

+358 40 824 3510

Kiinamyllynkatu 4-8

Turku

: https://orcid.org/0000-0002-4006-7977

Roivainen Group

Researchgate

Molecular Imaging; PET; Inflammation Imaging

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.

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Pancreatic metabolism, blood flow, and β-cell function in obese humans. (2014)
- Journal of Clinical Endocrinology and Metabolism
Honka H, Hannukainen JC, Tarkia M, Karlsson H, Saunavaara V, Salminen P, Soinio M, Mikkola K, Kudomi N, Oikonen V, Haaparanta-Solin M, Roivainen A, Parkkola R, Iozzo P, Nuutila P.
Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice (2014)
- Arteriosclerosis, Thrombosis, and Vascular Biology
Rinne P, Silvola JM, Hellberg S, Ståhle M, Liljenbäck H, Salomäki H, Koskinen E, Nuutinen S, Saukko P, Knuuti J, Saraste A, Roivainen A, Savontaus E
Synthesis of multi-galactose-conjugated 2´-O-methyl oligoribonucleotides and their in vivo imaging with positron emission tomography (2014)
- Bioorganic and Medicinal Chemistry
Jussi Mäkilä, Satish Jadhav, Anu Kiviniemi, Meeri Käkelä, Heidi Liljenbäck, Päivi Poijärvi-Virta, Tiina Laitala-Leinonen, Harri Lönnberg, Anne Roivainen, Pasi Virta
The use of positron emission tomography (PET) imaging as a diagnostic procedure when vasculitis is suspected (2014)
- Scandinavian Journal of Rheumatology
Salomäki Soile, Taimen Kirsi, Silvola Johanna, Kemppainen Jukka, Hohenthal Ulla, Saraste Antti, Roivainen Anne, Pirilä Laura.
Use of a clinical PET/MR scanner for preclinical research with first results (2014)
- EJNMMI Physics
Karthik Chary, Jarmo Teuho, Jenni Virta, Hannu Sipilä, Virva Saunavaara, Anne Roivainen and Mika Teräs
Using 5-deoxy-5-[F-18] fluororibose to glycosylate peptides for positron emission tomography (2014)
- Nature Protocols
Li XG, Helariutta K, Roivainen A, Jalkanen S, Knuuti J, Airaksinen AJ
Widespread vascular inflammation in a patient with antineutrophil cytoplasmic antibody-associated vasculitis as detected by positron emission tomography. (2014)
- European Journal of Nuclear Medicine and Molecular Imaging
Salomäki SP, Kemppainen J, Aho H, Hohenthal U, Kain R, Koivuviita N, Badeau RM, Seppänen M, Silvoniemi A, Roivainen A, Pirilä L.
[(18)F]-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography in ResponseEvaluation of Oncolytic Adenovirus Treatmentsof Patients with Advanced Cancer (2013)
- Human Gene Therapy
Anniina Koski, Helena Ahtinen, Heidi Liljenback, Anne Roivainen, Anu Koskela, Minna Oksanen, Kaarina Partanen, Leena Laasonen, Kalevi Kairemo, Timo Joensuu, Akseli Hemminki
Celiac Disease-Specific TG2-Targeted Autoantibodies Inhibit Angiogenesis Ex Vivo and In Vivo in Mice by Interfering with Endothelial Cell Dynamics (2013)
- PLoS ONE
Kalliokoski S, Sulic AM, Korponay-Szabo IR, Szondy Z, Frias R, Perez MA, Martucciello S, Roivainen A, Pelliniemi LJ, Esposito C, Griffin M, Sblattero D, Maki M, Kaukinen K, Lindfors K, Caja S
Characterization of hepatic tumors using [11C]metomidate through positron emission tomography: comparison with [11C]acetate (2013)
- EJNMMI Research
Roivainen A, Naum A, Nuutinen H, Leino R, Nurmi H, Någren K, Parkkola R, Virtanen J, Kallajoki M, Kujari H, Ovaska J, Roberts P, Seppänen M
Correlation of F-18-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs (2013)
- European Journal of Nuclear Medicine and Molecular Imaging
Roivainen A, Hautaniemi S, Mottonen T, Nuutila P, Oikonen V, Parkkola R, Pricop L, Ress R, Seneca N, Seppanen M, Yli-Kerttula T
In Vivo Imaging of Prostate Cancer Using [Ga-68]-Labeled Bombesin Analog BAY86-7548 (2013)
- Clinical Cancer Research
Kahkonen E, Jambor I, Kemppainen J, Lehtio K, Gronroos TJ, Kuisma A, Luoto P, Sipila HJ, Tolvanen T, Alanen K, Silen J, Kallajoki M, Roivainen A, Schafer N, Schibli R, Dragic M, Johayem A, Valencia R, Borkowski S, Minn H
Nuclear imaging of inflammation: homing-associated molecules as targets (2013)
- EJNMMI Research
Autio A, Jalkanen S, Roivainen A
Plasma Pharmacokinetics, Whole-Body Distribution, Metabolism, and Radiation Dosimetry of Ga-68 Bombesin Antagonist BAY 86-7548 in Healthy Men (2013)
- Journal of Nuclear Medicine
Roivainen A, Kahkonen E, Luoto P, Borkowski S, Hofmann B, Jambor I, Lehtio K, Rantala T, Rottmann A, Sipila H, Sparks R, Suilamo S, Tolvanen T, Valencia R, Minn H
Preclinical Evaluation of a Radioiodinated Fully Human Antibody for In Vivo Imaging of Vascular Adhesion Protein-1-Positive Vasculature in Inflammation (2013)
- Journal of Nuclear Medicine
Autio A, Vainio PJ, Suilamo S, Mali A, Vainio J, Saanijoki T, Noponen T, Ahtinen H, Luoto P, Teras M, Jalkanen S, Roivainen A
Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-l-lysyl-glycine linkage (2013)
- Nuclear Medicine and Biology
Yim CB, Mikkola K, Fagerholm V, Elomaa VV, Ishizu T, Rajander J, Schlesinger J, Roivainen A, Nuutila P, Solin O
Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage (2013)
- Journal of Labelled Compounds and Radiopharmaceuticals
Journal of Labelled Compounds and Radiopharmaceuticals Yim CB, Mikkola K, Fagerholm V, Rajander J, Elomaa VV, Ishizu T, Schlesinger J, Roivainen A, Nuutila P, Solin O
Translating the concept of peptide labeling with 5-deoxy-5-[F-18] fluororibose into preclinical practice: F-18-labeling of Siglec-9 peptide for PET imaging of inflammation (2013)
- Chemical Communications
Li XG, Autio A, Ahtinen H, Helariutta K, Liljenback H, Jalkanen S, Roivainen A, Airaksinen AJ
A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia. (2012)
- EJNMMI Research
Lankinen P, Lehtimäki K, Hakanen AJ, Roivainen A, Aro HT
Amyloid Targeting Tracer [F-18]flutemetamol is Accumulated in Atherosclerotic Plaques (2012)
- European Journal of Nuclear Medicine and Molecular Imaging
Hellberg SE, Saraste A, Silvola JMU, Eskola O, Liljenback H, Laine J, Lehikoinen P, Saukko P, Horkko S, Knuuti J, Roivainen A