Anne Roivainen
Professor of Preclinical Imaging and Drug Research
aroivan@utu.fi +358 40 824 3510 Kiinamyllynkatu 4-8 Turku |
Molecular Imaging; PET; Inflammation Imaging
http://inflammation-imaging.utu.fi
Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.
Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.
- Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)
- American Journal of Human Genetics
- Efficient radiosynthesis of a new folate receptor-targeting PET tracer, [18F]fluoronicotinic acid labeled folate, for imaging lung fibrosis (2023)
- Nuclear Medicine and Biology
- High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities (2023)
- Frontiers in Immunology
- Improvement of the female mouse computational model developed at CDTN (2023)
- Brazilian Journal of Development
- In Vivo Imaging of [60]Fullerene-Based Molecular Spherical Nucleic Acids by Positron Emission Tomography (2023)
- Molecular Pharmaceutics
- Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study (2023)
- Advanced Functional Materials
- Mannose Receptor (CD206) Targeting with Aluminum Fluoride-18 Labeled Mannosylated Dextran (2023)
- Nuclear Medicine and Biology
- Pretargeted PET imaging of trans-cyclooctene functionalized spherical nucleic acids (2023)
- Nuclear Medicine and Biology
- Targeting mammary-derived growth inhibitor for positron emission tomography imaging of breast cancer brain metastasis (2023)
- Nuclear Medicine and Biology
Airaksinen Anu, Laakkonen Pirjo, Li Xiang-Guo - Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids (2023)
- ACS Omega
- Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis (2023)
- Journal of Nuclear Cardiology
- 68Ga-Citrate Positron Emission Tomography of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates (2022)
- Journal of Nuclear Medicine
- Comparing Folate Receptor β Targeting Tracers in Experimental Myocarditis Model (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
- Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine(Front. Immunol., (2022), 13, (821423), 10.3389/fimmu.2022.821423) (2022)
- Frontiers in Immunology
- Development of [18F]AmBF3 Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [18F]AmBF3-PEG7-Tyr3-Octreotide in an AR42J Pancreatic Carcinoma Model (2022)
- Bioconjugate Chemistry
- Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine (2022)
- Frontiers in Immunology
- Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography (2022)
- European Heart Journal
- [Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice (2022)
- Frontiers in Immunology
- O-59 - Radiolabeling and biological evaluation of functionalized spherical nucleic acids (2022)
- Nuclear Medicine and Biology
- PET imaging of bacteria (2022) Nuclear Medicine and Molecular Imaging Signore Alberto, Conserva Martina, Varani Michela, Galli Filippo, Lauri Chiara, Velikyan Irina, Roivainen Anne