MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Testicular dysgenesis syndrome and the development and occurrence of male reproductive disordersNear-miss apparent SIDS from adrenal crisis (2005)
- Toxicology and Applied PharmacologyMolecular and Cellular EndocrinologyJournal of PediatricsJournal of Cell Science
Virtanen HE, Rajpert-De Meyts E, Main KM, Skakkebaek NE, Toppari J
The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosisAdult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat linesOrexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis (2005)
Wang Y, Suominen JS, Parvinen M, Rivero-Muller A, Kiiveri S, Heikinheimo M, Robbins I, Toppari J
Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries (2004)
- Toxicological Sciences
Simanainen U, Adamsson A, Tuomisto JT, Miettinen HM, Toppari J, Tuomisto J, Viluksela M
Difference in prevalence of congenital cryptorchidism in infants between two Nordic countriesProtection from radiation-induced male germ cell loss by sphingosine-1-phosphate (2004)
- American Journal of Epidemiology
Jensen TK, Jørgensen N, Punab M, Haugen TB, Suominen J, Zilaitiene B, Horte A, Andersen AG, Carlsen E, Magnus Ø, Matulevicius V, Nermoen I, Vierula M, Keiding N, Toppari J, Skakkebaek NE
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testisSurvivin expression in rat testis is upregulated by stem-cell factor (2004)
- LancetBiology of Reproduction
Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J
[High and increasing prevalence of cryptorchidism in Denmark]. (2004)
- EndocrinologyMolecular and Cellular Endocrinology
Barreiro ML, Gaytan F, Castellano JM, Suominen JS, Roa J, Gaytan M, Aguilar E, Dieguez C, Toppari J, Tena-Sempere M
(2004)
- Ugeskrift for Laeger
Boisen KA, Kaleva M, Main KM, Virtanen H, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J
Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene (2004)
- Biology of Reproduction
Ahtiainen M, Toppari J, Poutanen M, Huhtaniemi I
(2004)
Gassner HL, Toppari J, Quinteiro González S, Miller WL
Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factorsEvidence for a role of glycogen synthase kinase-3 beta in rodent spermatogenesis (2004)
Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, Navarro VM, Casanueva FF, Aguilar E, Toppari J, Diéguez C, Tena-Sempere M
(2004)
- Endocrinology
Barreiro ML, Pineda R, Navarro VM, Lopez M, Suominen JS, Pinilla L, Señaris R, Toppari J, Aguilar E, Diéguez C, Tena-Sempere M
Paracrine regulation of mammalian oocyte maturation and male germ cell survival (2004)
- Proceedings of the National Academy of Sciences of the United States of America
Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA, Hsueh AJ
Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat linesTumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist (2004)
- Toxicological SciencesEuropean Journal of Endocrinology
Simanainen U, Haavisto T, Tuomisto JT, Paranko J, Toppari J, Tuomisto J, Peterson RE, Viluksela M
(2004)
Otala M, Suomalainen L, Pentikäinen MO, Kovanen P, Tenhunen M, Erkkilä K, Toppari J, Dunkel L
(2004)
Wang Y, Suominen JS, Hakovirta H, Parvinen M, Martinand-Mari C, Toppari J, Robbins I
2004
Suominen JS, Wang Y, Kaipia A, Toppari J
Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis (2003)
- Biology of Reproduction
Barreiro ML, Suominen JS, Gaytán F, Pinilla L, Chopin LK, Casanueva FF, Diéguez C, Aguilar E, Toppari J, Tena-Sempere M
Effects of 4-tert-octylphenol, 4-tert-butylphenol, and diethylstilbestrol on prenatal testosterone surge in the rat (2003)
- Reproductive Toxicology
Haavisto TE, Adamsson NA, Myllymäki SA, Toppari J, Paranko J
(2003)
- Endocrinology
Rulli SB, Ahtiainen P, Mäkelä S, Toppari J, Poutanen M, Huhtaniemi I
(2003)
- Journal of Andrology
Guo TB, Chan KC, Hakovirta H, Xiao Y, Toppari J, Mitchell AP, Salameh WA