MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance (2015)
- Oncotarget
Ventelä S, Sittig E, Mannermaa L, Mäkelä J-A, Kulmala J, Löyttyniemi E, Strauss L, Cárpen O, Toppari J, Grénman R, Westermarck J
Clinical features of celiac disease: a prospective birth cohort. (2015)
- Pediatrics
Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S; for the TEDDY Study Group
Cryptorchidism and Fertility (2015)
- Endocrinology and Metabolism Clinics of North America
Virtanen H., Toppari J.
DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium. (2015)
- Biology of Reproduction
Korhonen HM, Yadav RP, Da Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N.
E2F1 controls germ cell apoptosis during the first wave of spermatogenesis (2015)
- Andrology
Rotgers E, Nurmio M, Pietila E, Cisneros-Montalvo S, Toppari J
Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes (2015)
- Diabetes Care
Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, Leon-Novelo LG, Vehik K, Casella G, Simell O, Ziegler AG, Rewers MJ, Lernmark A, Hagopian W, She JX, Krischer JP, Akolkar B, Schatz DA, Atkinson MA, Triplett EW; the TEDDY Study Group
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals (2015)
- Endocrine Reviews
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller R
Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015)
- Endocrine Reviews
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT
GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells (2015)
- Endocrinology
Schrade A, Kyronlahti A, Akinrinade O, Pihlajoki M, Hakkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M
Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes (2015)
- Diabetologia
Kondrashova A, Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hyoty H
Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives (2015)
- Endocrinology
Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Lawrence BP, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ
Male Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union (2015)
- Journal of Clinical Endocrinology and Metabolism
Hauser R, Skakkebaek NE, Hass U, Toppari J, Juul A, Andersson AM, Kortenkamp A, Heindel JJ, Trasande L
Manufacturing doubt about endocrine disrupter science - A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012" (2015)
- Regulatory Toxicology and Pharmacology
Bergman Å., Becher G., Blumberg B., Bjerregaard P., Bornman R., Brandt I., Casey S., Frouin H., Giudice L., Heindel J., Iguchi T., Jobling S., Kidd K., Kortenkamp A., Lind P., Muir D., Ochieng R., Ropstad E., Ross P., Skakkebaek N., Toppari J., Vandenberg L., Woodruff T., Zoeller R.
Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease (2015)
- Journal of Autoimmunity
Lempainen J, Laine AP, Hammais A, Toppari J, Simell O, Veijola R, Knip M, Ilonen J
Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) (2015)
- Diabetes Care
Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She JX, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ; the TEDDY Study Group
Retromer vesicles interact with RNA granules in haploid male germ cells (2015)
- Molecular and Cellular Endocrinology
Da Ros M, Hirvonen N, Olotu O, Toppari J, Kotaja N.
Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study (2015)
- Diabetes
Törn C, Hadley D, Lee HS, Hagopian W, Lernmark A, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J; the TEDDY Study Group
Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility (2015)
- Diabetes
Moulder R, Bhosale SD, Erkkila T, Laajala E, Salmi J, Nguyen EV, Kallionpaa H, Mykkanen J, Vaha-Makila M, Hyoty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lahdesmaki H, Simell O, Lahesmaa R
The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study (2015)
- Diabetologia
Krischer JP, Lynch KF, Schatz DA, Ilonen J, Lernmark A, Hagopian WA, Rewers MJ, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Bonifacio E; the TEDDY Study Group
Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. (2014)
- Human Reproduction
Jensen TK, Swan S, Jørgensen N, Toppari J, Redmon B, Punab M, Drobnis EZ, Haugen TB, Zilaitiene B, Sparks AE, Irvine DS, Wang C, Jouannet P, Brazil C, Paasch U, Salzbrunn A, Skakkebæk NE, Andersson AM.