MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure. (2016)
- European Journal of Public Health
Le Moal J, Sharpe RM, Jϕrgensen N, Levine H, Jurewicz J, Mendiola J, Swan SH, Virtanen H, Christin-Maître S, Cordier S, Toppari J, Hanke W; in name of the HURGENT Network.
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism (2016)
- Biology Open
Kettunen KM, Karikoski R, Hamalainen RH, Toivonen TT, Antonenkov VD, Kulesskaya N, Voikar V, Holtta-Vuori M, Ikonen E, Sainio K, Jalanko A, Karlberg S, Karlberg N, Lipsanen-Nyman M, Toppari J, Jauhiainen M, Hiltunen JK, Jalanko H, Lehesjoki AE
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. (2016)
- European Urology
Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N
A detailed protocol for a rapid analysis of testicular cell populations using flow cytometry (2015)
- Andrology
Rotgers E, Cisneros-Montalvo S, Jahnukainen K, Sandholm J, Toppari J, Nurmio M
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes (2015)
- Clinical Epigenetics
Acevedo N, Reinius LE, Vitezic M, Fortino V, Soderhall C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyoty H, Greco D, Kere J
Age at Gluten Introduction and Risk of Celiac Disease (2015)
- Pediatrics
Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang JM, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D; for the TEDDY STUDY GROUP
A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY (2015)
- BMC Pediatrics
Lonnrot M, Lynch K, Larsson HE, Lernmark A, Rewers M, Hagopian W, She JX, Simell O, Ziegler AG, Akolkar B, Krischer J, Hyoty H; and The TEDDY study group
Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children (2015)
- Journal of Pediatric Gastroenterology and Nutrition
Lammi A, Arikoski P, Simell S, Kinnunen T, Simell V, Paavanen-Huhtala S, Hinkkanen A, Veijola R, Knip M, Toppari J, Vaarala O, Simell O, Ilonen J.
Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study (2015)
- Environmental Health: A Global Access Science Source
Jaakko J. Koskenniemi, Helena E. Virtanen, Hannu Kiviranta, Ida N. Damgaard, Jaakko Matomäki, Jørgen M. Thorup, Timo Hurme, Niels E. Skakkebaek, Katharina M. Main, Jorma Toppari
B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study (2015)
- PLoS ONE
Kantola K, Hedman L, Tanner L, Simell V, Makinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyoty H, Toppari J, Simell O, Hedman K, Soderlund-Venermo M
CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance (2015)
- Oncotarget
Ventelä S, Sittig E, Mannermaa L, Mäkelä J-A, Kulmala J, Löyttyniemi E, Strauss L, Cárpen O, Toppari J, Grénman R, Westermarck J
Clinical features of celiac disease: a prospective birth cohort. (2015)
- Pediatrics
Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S; for the TEDDY Study Group
Cryptorchidism and Fertility (2015)
- Endocrinology and Metabolism Clinics of North America
Virtanen H., Toppari J.
DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium. (2015)
- Biology of Reproduction
Korhonen HM, Yadav RP, Da Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N.
E2F1 controls germ cell apoptosis during the first wave of spermatogenesis (2015)
- Andrology
Rotgers E, Nurmio M, Pietila E, Cisneros-Montalvo S, Toppari J
Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes (2015)
- Diabetes Care
Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, Leon-Novelo LG, Vehik K, Casella G, Simell O, Ziegler AG, Rewers MJ, Lernmark A, Hagopian W, She JX, Krischer JP, Akolkar B, Schatz DA, Atkinson MA, Triplett EW; the TEDDY Study Group
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals (2015)
- Endocrine Reviews
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller R
Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015)
- Endocrine Reviews
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT
GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells (2015)
- Endocrinology
Schrade A, Kyronlahti A, Akinrinade O, Pihlajoki M, Hakkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M
Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes (2015)
- Diabetologia
Kondrashova A, Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hyoty H