MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers (2016)
- Matters
Ventelä S, Mäkelä J-A, Sears RC, Toppari J, Westermarck J
Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life (2016)
- Clinical and Vaccine Immunology
Borges IC, Andrade DC, Cardoso MRA, Toppari J, Vaha-Makila M, Ilonen J, Knip M, Hyoty H, Veijola R, Simell O, Jartti T, Kayhty H, Ruuskanen O, Nascimento-Carvalho CM
Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing (2016)
- Journal of Diabetes Research
Lernmark B, Lynch K, Baxter J, Roth R, Simell T, Smith L, Swartling U, Johnson SB; and Teddy Study Group
Reduced β-cell function in early preclinical type 1 diabetes (2016)
- European Journal of Endocrinology
Koskinen MK, Helminen O, Matomäki J, Aspholm S, Mykkänen J, Mäkinen M, Simell V, Vähä-Mäkilä M, Simell T, Ilonen J, Knip M, Veijola R, Toppari J, Simell OG
Reversion of beta-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study (2016)
- Diabetes Care
Vehik K, Lynch KF, Schatz DA, Akolkar B, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Lernmark A, Bonifacio E, Krischer JP
Semen quality improves marginally during young adulthood: a longitudinal follow-up study (2016)
- Human Reproduction
Perheentupa A, Sadov S, Rönkä R, Virtanen HE, Rodprasert W, Vierula M, Jørgensen N, Skakkebæk NE, Toppari J:
Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes (2016)
- Journal of Clinical Endocrinology and Metabolism
Mäkinen M, Mykkänen J, Koskinen M, Simell V, Veijola R, Hyöty H, Ilonen J, Knip M, Simell O, Toppari J
Testicular Growth During Puberty in Boys With and Without a History of Congenital Cryptorchidism (2016)
- Journal of Clinical Endocrinology and Metabolism
Sadov S, Koskenniemi JJ, Virtanen HE, Perheentupa A, Petersen JH, Skakkebaek NE, Main KM, Toppari J
The Path Forward on Endocrine Disruptors Requires Focus on the Basics (2016)
- Toxicological Sciences
Zoeller RT, Bergman A, Becher G, Bjerregaard P, Bomman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek N, Toppari J, Vandenberg L
The role of innate immunity in Type 1 Diabetes (T1D) (2016)
- Scandinavian Journal of Immunology
Vaha-Makila M, Hellman V, Mykkanen J, Paavanen-Huhtala S, Ronnemaa T, Simell O, Knip M, Ilonen J, Veijola R, Toppari J
Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure. (2016)
- European Journal of Public Health
Le Moal J, Sharpe RM, Jϕrgensen N, Levine H, Jurewicz J, Mendiola J, Swan SH, Virtanen H, Christin-Maître S, Cordier S, Toppari J, Hanke W; in name of the HURGENT Network.
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism (2016)
- Biology Open
Kettunen KM, Karikoski R, Hamalainen RH, Toivonen TT, Antonenkov VD, Kulesskaya N, Voikar V, Holtta-Vuori M, Ikonen E, Sainio K, Jalanko A, Karlberg S, Karlberg N, Lipsanen-Nyman M, Toppari J, Jauhiainen M, Hiltunen JK, Jalanko H, Lehesjoki AE
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. (2016)
- European Urology
Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N
A detailed protocol for a rapid analysis of testicular cell populations using flow cytometry (2015)
- Andrology
Rotgers E, Cisneros-Montalvo S, Jahnukainen K, Sandholm J, Toppari J, Nurmio M
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes (2015)
- Clinical Epigenetics
Acevedo N, Reinius LE, Vitezic M, Fortino V, Soderhall C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyoty H, Greco D, Kere J
Age at Gluten Introduction and Risk of Celiac Disease (2015)
- Pediatrics
Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang JM, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D; for the TEDDY STUDY GROUP
A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY (2015)
- BMC Pediatrics
Lonnrot M, Lynch K, Larsson HE, Lernmark A, Rewers M, Hagopian W, She JX, Simell O, Ziegler AG, Akolkar B, Krischer J, Hyoty H; and The TEDDY study group
Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children (2015)
- Journal of Pediatric Gastroenterology and Nutrition
Lammi A, Arikoski P, Simell S, Kinnunen T, Simell V, Paavanen-Huhtala S, Hinkkanen A, Veijola R, Knip M, Toppari J, Vaarala O, Simell O, Ilonen J.
Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study (2015)
- Environmental Health: A Global Access Science Source
Jaakko J. Koskenniemi, Helena E. Virtanen, Hannu Kiviranta, Ida N. Damgaard, Jaakko Matomäki, Jørgen M. Thorup, Timo Hurme, Niels E. Skakkebaek, Katharina M. Main, Jorma Toppari
B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study (2015)
- PLoS ONE
Kantola K, Hedman L, Tanner L, Simell V, Makinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyoty H, Toppari J, Simell O, Hedman K, Soderlund-Venermo M