Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes



: Acevedo N, Reinius LE, Vitezic M, Fortino V, Soderhall C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyoty H, Greco D, Kere J

Publisher: BIOMED CENTRAL LTD

: 2015

: Clinical Epigenetics

: CLINICAL EPIGENETICS

: CLIN EPIGENETICS

: ARTN 34

: 7

: 20

: 1868-7083

DOI: https://doi.org/10.1186/s13148-015-0064-6


Conclusions: This study reveals that susceptibility loci for complex inflammatory diseases (for example, IRF5, NOD2, and PTGER4) and genes encoding histone modifiers and chromatin remodeling factors (for example, HDAC4, KDM2A, KDM2B, JARID2, ARID3A, and SMARCD3) undergo DNA methylation changes in leukocytes during early childhood. These results open new perspectives to understand leukocyte maturation and provide a catalogue of CpG sites that may need to be corrected for age effects when performing DNA methylation studies in children.




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