Jorma Toppari
MD, PhD
jortop@utu.fi +358 29 450 2826 +358 40 180 2600 Kiinamyllynkatu 10 Turku Office: C5 floor ORCID identifier: https://orcid.org/0000-0003-2228-334X(external) |
Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes
Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.
The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.
Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology
- Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort (2023)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection (2023)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls (2023)
- Autoimmunity
(A1 Refereed original research article in a scientific journal) - Environmental Influences on Male Reproductive Health (2023) Andrology: Male Reproductive Health and Dysfunction Brinkworth Martin H., Toppari Jorma
(D2 Article in a professional compilation book) - Environmental toxicants and male fertility (2023)
- Best Practice and Research: Clinical Obstetrics and Gynaecology
(A1 Refereed original research article in a scientific journal) - Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression (2023)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative (2023)
- Toxics
(A1 Refereed original research article in a scientific journal) - Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children (2023)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study (2023)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study (2023)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine (2023)
- Journal of Medical Virology
(A1 Refereed original research article in a scientific journal) - HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study (2023)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Imatinib decreases DNA synthesis, germ cell survival, and stem cell proliferation and differentiation in rodent testis (2023)
- Toxicology Letters
(Other publication) - Incidence of Pediatric Celiac Disease Varies by Region (2023)
- American Journal of Gastroenterology
(A1 Refereed original research article in a scientific journal) - Intake and sources of dietary fibre and dietary fibre fractions in Finnish children (2023)
- British Journal of Nutrition
(A1 Refereed original research article in a scientific journal) - Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study (2023)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study (2023)
- The Lancet Child & Adolescent Health
(A1 Refereed original research article in a scientific journal) - Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias (2023)
- Chemosphere
(A1 Refereed original research article in a scientific journal) - Longitudinal consumption of fruits and vegetables and risk of asthma by 5 years of age (2023)
- Pediatric Allergy and Immunology
(A1 Refereed original research article in a scientific journal) - Male fertility and semen quality are decreasing - Do we have the expertise to deal with this challenge? (2023)
- Acta Obstetricia et Gynecologica Scandinavica
(B1 Non-refereed article in a scientific journal)