Laura Pekkarinen

Department of Clinical Medicine (Faculty of Medicine)

lepekk@utu.fi

Expertese

Anorexia nervosa is associated with higher brain mu-opioid receptor availability (2025)
- Molecular Psychiatry
Pak, Kyoungjune; Tuisku, Jouni; Karlsson, Henry K.; Hirvonen, Jussi; Rebelos, Eleni; Pekkarinen, Laura; Sun, Lihua; Latva-Rasku, Aino; Helin, Semi; Rajander, Johan; Karukivi, Max; Nuutila, Pirjo; Nummenmaa, Lauri
Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test (2025)
- Journal of the Endocrine Society
Honka, Miikka-Juhani; Rebelos, Eleni; Pekkarinen, Laura; Tuomola, Nelli; Latva-Rasku, Aino; Koukkari, Leena; Immonen, Heidi; Mari, Andrea; Kalliokoski, Kari K; Hannukainen, Jarna C; Nuutila, Pirjo
SGLT2 Inhibitor Dapagliflozin Increases Skeletal Muscle and Brain Fatty Acid Uptake in Individuals With Type 2 Diabetes : A Randomized Double-Blind Placebo-Controlled Positron Emission Tomography Study (2024)
- Diabetes Care
Latva-Rasku, Aino; Rebelos, Eleni; Tuisku, Jouni; Aarnio, Richard; Bhowmik, Achol; Keskinen, Helmi; Laurila, Sanna; Lahesmaa-Hatting, Minna; Pekkarinen, Laura; Isackson, Henrik; Kirjavainen, Anna K.; Koffert, Jukka; Heurling, Kerstin; Nummenmaa, Lauri; Ferrannini, Ele; Oldgren, Jonas; Oscarsson, Jan; Nuutila, Pirjo
Association of CNR1 gene and cannabinoid 1 receptor protein in the human brain (2023)
- Journal of Neuroscience Research
Pak Kyoungjune, Kantonen Tatu, Pekkarinen Laura, Nuutila Pirjo, Nummenmaa Lauri
Insulin sensitivity and endocannabinoid function as risk factors for obesity: Positron emission tomography studies of insulin sensitivity and CB1 receptors (2023) Pekkarinen Laura
Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study (2023)
- Journal of Cerebral Blood Flow and Metabolism
Rebelos Eleni, Latva-Rasku Aino, Koskensalo Kalle, Pekkarinen Laura, Saukko Ekaterina, Ihalainen Jukka, Honka Miikka-Juhani, Tuisku Jouni, Bucci Marco, Laurila Sanna, Rajander Johan, Salminen Paulina, Nummenmaa Lauri, Jansen Jacobus FA, Ferrannini Ele, Nuutila Pirjo
Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight (2023)
- Obesity
Pekkarinen L., Kantonen T., Oikonen V., Haaparanta-Solin M., Aarnio R., Dickens A.M., von Eyken A., Latva-Rasku A., Dadson P., Kirjavainen A.K., Rajander J., Kalliokoski K., Rönnemaa T., Nummenmaa L., Nuutila P.
Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids (2023)
- Journal of Clinical Endocrinology and Metabolism
Rebelos Eleni, Mari Andrea, Honka Miikka-Juhani, Pekkarinen Laura, Latva-Rasku Aino, Laurila Sanna, Rajander Johan, Salminen Paulina, Iida Hidehiro, Ferrannini Ele, Nuutila Pirjo
Aerobic Fitness is Associated with Cerebral mu-Opioid Receptor Activation in Healthy Humans (2022)
- Medicine and Science in Sports and Exercise
Saanijoki Tiina, Kantonen Tatu, Pekkarinen Laura, Kalliokoski Kari, Hirvonen Jussi, Malén Tuulia, Tuominen Lauri, Tuulari Jetro J, Arponen Eveliina, Nuutila Pirjo, Nummenmaa Lauri
Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB1 receptor availability (2022)
- International Journal of Obesity
Kantonen Tatu, Pekkarinen Laura, Karjalainen Tomi, Bucci Marco, Kalliokoski Kari, Haaparanta-Solin Merja, Aarnio Richard, Dickens Alex M., von Eyken Annie, Laitinen Kirsi, Houttu Noora, Kirjavainen Anna K., Helin Semi, Hirvonen Jussi, Rönnemaa Tapani, Nuutila Pirjo, Nummenmaa Lauri
Obesity risk is associated with brain glucose uptake and insulin resistance (2022)
- European Journal of Endocrinology
Pekkarinen Laura, Kantonen Tatu, Rebelos Eleni, Latva-Rasku Aino, Dadson Prince, Karjalainen Tomi, Bucci Marco, Kalliokoski Kari, Laitinen Kirsi, Houttu Noora, Kirjavainen Anna K, Rajander Johan, Rönnemaa Tapani, Nummenmaa Lauri, Nuutila Pirjo
Renal Sinus Fat Is Expanded in Patients with Obesity and/or Hypertension and Reduced by Bariatric Surgery Associated with Hypertension Remission (2022)
- Metabolites
Moritz Emilia, Dadson Prince, Saukko Ekaterina, Honka Miikka-Juhani, Koskensalo Kalle, Seppälä Kerttu, Pekkarinen Laura, Moriconi Diego, Helmiö Mika, Salminen Paulina, Nuutila Pirjo, Rebelos Eleni
μ-opioid receptor availability is associated with sex drive in human males (2022)
- Cognitive, Affective, and Behavioral Neuroscience
Nummenmaa Lauri, Jern Patrick, Malen Tuulia, Kantonen Tatu, Pekkarinen Laura, Lukkarinen Lasse, Sun Lihua, Nuutila Pirjo, Putkinen Vesa
Cerebral μ-opioid and CB1 receptor systems have distinct roles in human feeding behavior (2021)
- Translational Psychiatry
Kantonen Tatu, Karjalainen Tomi, Pekkarinen Laura, Isojärvi Janne, Kalliokoski Kari, Kaasinen Valtteri, Hirvonen Jussi, Nuutila Pirjo, Nummenmaa Lauri
Insulin-stimulated brain glucose uptake correlates negatively with peripheral insulin sensitivity already in the early phase of metabolic dysregulation (2021)
- Diabetologia
57 th EASD Annual Meeting of the European Association for the Study of Diabetes Pekkarinen L, Kantonen T, Karjalainen T, Bucci M, Rebelos E, Dadson P, Latva-Rasku A, Kalliokoski K, Laitinen K, Houttu N, Kirjavainen A, Ronnemaa T, Nummenmaa L, Nuutila P
Lihomisriski on yhteydessä aivojen insuliini- ja reseptorimuutoksiin (2021)
- Duodecim
Kantonen T., Pekkarinen L., Karjalainen T., Bucci M., Kalliokoski K., Haaparanta-Solin M., Aarnio R., Dickens A.M., von Eyken A., Laitinen K., Houttu N., Kirjavainen A.K., Helin S., Hirvonen J., Rönnemaa T., Nuutila P., Nummenmaa L.
Brain free fatty acid uptake is elevated in morbid obesity, and is irreversible 6 months after bariatric surgery: A positron emission tomography study (2020)
- Diabetes, Obesity and Metabolism
Eleni Rebelos, Jussi Hirvonen, Marco Bucci, Laura Pekkarinen, Mikko Nyman, Jarna C. Hannukainen, Patricia Iozzo, Paulina Salminen, Lauri Nummenmaa, Ele Ferrannini, Pirjo Nuutila