Alex-Mikael Barkoff

- Doctoral Researcher,
Paediatrics and Adolescent Medicine (Department of Clinical Medicine)
- Project Researcher,
Institute of Biomedicine (Faculty of Medicine)

ambark@utu.fi

Kiinamyllynkatu 10

Turku

Office: Mikro building, 3rd floor, room 354

ORCID identifier: https://orcid.org/0000-0003-0742-1580

Areas of expertise

Pertussis

Research

Serological pertussis studies, Evolution of B. pertussis, ECDC pertussis network projects

Publications

1 of 3

The effect of pertussis vaccination during pregnancy on the binding epitopes and avidity of anti-pertussis toxin IgG antibodies in infants and their mothersMacrolide-resistant Bordetella pertussis strain identified during an ongoing epidemic, Finland, January to October 2024 (2026)
- Journal of Infectious DiseasesEurosurveillance
Knuutila, Aapo; Ivaska, Lauri; Barkoff, Alex-Mikael; van Gageldonk, Pieter; Buisman, Annemarie; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
The evolution of pertactin expression in Belgian circulating B. pertussis strains, pre- and post-COVID-19 (2026)
- Microbiology spectrum
Martini, Helena; Soetens, Oriane; Niinikoski, Vili; Barkoff, Alex-Mikael; He, Qiushui; Piérard, Denis; Van Honacker, Eveline
(A1 Refereed original research article in a scientific journal)
Alterations in the expression of Bordetella pertussis antigens in relation to the use of acellular pertussis vaccine in Finland (2025)
- VaccineEmerging Infectious Diseases
Niinikoski, Vili; Barkoff, Alex-Mikael; Mertsola, Jussi; Holubova, Jana; Masin, Jiri; Sebo, Peter; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children (2025)
- VaccineEmerging microbes & infections
Anabe, Denise; Teräsjärvi, Johanna T.; Barkoff, Alex-Mikael; Knuutila, Aapo; Pape, Bernd; van Gageldonk, Pieter; Buisman, Annemarie; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Hinkuyskän laboratorioseuranta : nykytilanne ja tulevaisuuden haasteet (2025)
- DuodecimFrontiers in immunology
He, Qiushui; Barkoff, Alex-Mikael
(A2 Refereed review article in a scientific journal )
Pertussis epidemic in Slovenia in 2024—no pertactin-deficient or macrolide-resistant Bordetella pertussis isolates identifiedEffect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants (2025)
- Clinical Microbiology and InfectionEmerging microbes & infections
Kastrin, Tamara; Barkoff, Alex-Mikael; Seme, Katja; Kosec, Luka; Triglav, Tina; Šinkovec Zorko, Nadja; Rožič, Mojca; Mertsola, Jussi; He, Qiushui
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal)
Prior immunological memory to pertussis toxin affects the avidity development of anti-PT IgG antibodies after acellular pertussis booster vaccinationImmunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria- acellular pertussis vaccine: a randomised, double-blind, phase 2b trial (2025)
- Emerging microbes & infectionsLancet
Knuutila, Aapo; Ahvenainen, Niina; Barkoff, Alex-Mikael; Mertsola, Jussi; van Gageldonk, Pieter; Buisman, Annemarie; Valente Pinto, Marta; Kelly, Dominic; He, Qiushui
(A1 Refereed original research article in a scientific journal)
The effect of pertussis vaccination in pregnancy on the immunogenicity of acellular or whole-cell pertussis vaccination in Gambian infants (GaPS): a single-centre, randomised, controlled, double-blind, phase 4 trialPastern dermatitis outbreak associated with toxigenic and non-toxigenic Corynebacterium diphtheriae and non-toxigenic Corynebacterium ulcerans at a horse stable in Finland, 2021 (2025)
- Lancet Infectious DiseasesZoonoses and Public Health
Saso, Anja; Kanteh, Ebrima; Jeffries, David; Okoye, Michael; Mohammed, Nuredin; Kumado, Michelle; Roetynck, Sophie; Jobe, Haddijatou; Faal, Amadou; Roberts, Elishia; Gageldonk, Pieter; Buisman, Anne-Marie; Fröberg, Janeri; Cavell, Breeze; Lesne, Elodie; Barkoff, Alex-Mikael; He, Qiushui; Tanha, Kiarash; Bibi, Sagida; Kelly, Dominic; Diavatopoulos, Dimitri; Kampmann, Beate; Gambian Pertussis Study Team; members of the PERISCOPE consortium
(A1 Refereed original research article in a scientific journal)
A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens (2024)
- Journal of Immunological Methods
Pinto, Marta Valente; Barkoff, Alex-Mikael; Bibi, Sagida; Knuutila, Aapo; Teräsjärvi, Johanna; Clutterbuck, Elizabeth; Gimenez-Fourage, Sophie; Pagnon, Anke; van Gaans-van den Brink, Jacqueline A.M.; Corbiere, Veronique; De Montfort, Aymeric; Saso, Anja; Jobe, Haddijatou; Roetynck, Sophie; Kampmann, Beate; Simonetti, Elles; Diavatopoulos, Dimitri; Lambert, Eleonora E.; Mertsola, Jussi; Blanc, Pascal; van Els, Cécile A. C. M.; Dominic Kelly, Dominic; He, Qiushui; The PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
Bordetella pertussis isolates in Finland after acellular vaccination : serotype change and biofilm formation (2024)
- Clinical Microbiology and InfectionJournal of Clinical Microbiology
Niinikoski, Vili; Barkoff, Alex-Mikael; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Long-term COVID-19 vaccine- and Omicron infection-induced humoral and cell-mediated immunity (2024)
- Frontiers in immunologyFrontiers in immunology
Belik, Milja; Reinholm, Arttu; Kolehmainen, Pekka; Heroum, Jemna; Maljanen, Sari; Altan, Eda; Österlund, Pamela; Laine, Larissa; Ritvos, Olli; Pasternack, Arja; Naves, Rauno A.; Iakubovskaia, Alina; Barkoff, Alex-Mikael; He, Qiushui; Lempainen, Johanna; Tähtinen, Paula A.; Ivaska, Lauri; Jalkanen, Pinja; Julkunen, Ilkka; Kakkola, Laura
(A1 Refereed original research article in a scientific journal)
(2024)
Miettinen, Milja; Barkoff, Alex-Mikael; Nyqvist, Aino; Savolainen-Kopra, Carita; Antikainen, Jenni; Mertsola, Jussi; Ivaska, Lauri; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia (2024)
Barkoff, Alex-Mikael; Kastrin, Tamara; Seme, Katja; Vitek, Marta Grgič; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Antibody avidity to pertussis toxin after acellular pertussis vaccination and infection (2023)
Knuutila Aapo, Dalby Tine, Ahvenainen Niina, Barkoff Alex-Mikael, Jørgensen Charlotte Sværke, Fuursted Kurt, Mertsola Jussi, He Qiushui
(A1 Refereed original research article in a scientific journal)
Automated EuroFlow approach for standardized in-depth dissection of human circulating B-cells and plasma cells (2023)
Delgado Alejandro H., Fluxa Rafael, Perez-Andres Martin, Diks Annieck M., van Gaans van den Brink Jacqueline A. M., Barkoff Alex-Mikael, Blanco Elena, Torres-Valle Alba, Berkowska Magdalena A., Grigore Georgiana, van Dongen J. . J. . M., Orfao Alberto; on behalf of The PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
(2023)
Knuutila Aapo, Barkoff Alex Mikael, Ivaska Lauri, Tenhu Elina, Teräsjärvi Johanna, van Gageldonk Pieter, Buisman Annemarie, Mertsola Jussi, He Qiushui; and PERISCOPE consortium
(A1 Refereed original research article in a scientific journal)
(2023)
Keech Cheryl, Miller Vicki E, Rizzardi Barbara, Hoyle Christopher, Pryor Melinda J, Ferrand Jonathan, Solovay Ken, Thalen Marcel, Noviello Stephanie, Goldstein Peter, Gorringe Andrew, Cavell Breeze, He Qiushui, Barkoff Alex-Mikael, Rubin Keith, Locht Camille
(A1 Refereed original research article in a scientific journal)
(2023)
Grönthal TSC, Lehto AK, Aarnio SS, Eskola EK, Aimo-Koivisto EM, Karlsson T, Koskinen HI, Barkoff AM, He Q, Lienemann T, Rimhanen-Finne R, Mykkänen A
(A1 Refereed original research article in a scientific journal)
Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (2023)
Knuutila Aapo, Harju Inka, Korhonen Suvi, Mäkelä Joonatan, Backström Lucas, Barkoff Alex-Mikael, He Qiushui
(B1 Non-refereed article in a scientific journal)
Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood (2022)
van der Pan Kyra, de Bruin-Versteeg Sandra, Damasceno Daniela, Hernandez-Delgado Alejandro, van der Sluijs-Gelling Alita J, van den Bossche Wouter BL, de Laat Inge F, Diez Paula, Naber Birgitta AE, Diks Annieck M, Berkowska Magdalena A, de Mooij Bas, Groenland Rick J, de Bie Fenna J, Khatri Indu, Kassem Sara, de Jager Anniek L, Louis Alesha, Almeida Julia, van Gaans-van den Brink Jacqueline AM, Barkoff Alex-Mikael, He Qiushui, Ferwerda Gerben, Versteegen Pauline, Berbers Guy AM, Orfao Alberto, van Dongen Jacques JM, Teodosio Cristina
(A1 Refereed original research article in a scientific journal)