Alex-Mikael Barkoff

- Doctoral Researcher,
Paediatrics and Adolescent Medicine (Department of Clinical Medicine)
- Project Researcher,
Institute of Biomedicine (Faculty of Medicine)

ambark@utu.fi

Kiinamyllynkatu 10

Turku

Office: Mikro building, 3rd floor, room 354

ORCID identifier: https://orcid.org/0000-0003-0742-1580(external)

Areas of expertise

Pertussis

Research

Serological pertussis studies, Evolution of B. pertussis, ECDC pertussis network projects

Publications

1 of 3

Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children (2025)
- Vaccine
Anabe, Denise; Teräsjärvi, Johanna T.; Barkoff, Alex-Mikael; Knuutila, Aapo; Pape, Bernd; van Gageldonk, Pieter; Buisman, Annemarie; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Pertussis epidemic in Slovenia in 2024—no pertactin-deficient or macrolide-resistant Bordetella pertussis isolates identified (2025)
- Clinical Microbiology and Infection
Kastrin, Tamara; Barkoff, Alex-Mikael; Seme, Katja; Kosec, Luka; Triglav, Tina; Šinkovec Zorko, Nadja; Rožič, Mojca; Mertsola, Jussi; He, Qiushui
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal)
The effect of pertussis vaccination in pregnancy on the immunogenicity of acellular or whole-cell pertussis vaccination in Gambian infants (GaPS): a single-centre, randomised, controlled, double-blind, phase 4 trial (2025)
- Lancet Infectious Diseases
Saso, Anja; Kanteh, Ebrima; Jeffries, David; Okoye, Michael; Mohammed, Nuredin; Kumado, Michelle; Roetynck, Sophie; Jobe, Haddijatou; Faal, Amadou; Roberts, Elishia; Gageldonk, Pieter; Buisman, Anne-Marie; Fröberg, Janeri; Cavell, Breeze; Lesne, Elodie; Barkoff, Alex-Mikael; He, Qiushui; Tanha, Kiarash; Bibi, Sagida; Kelly, Dominic; Diavatopoulos, Dimitri; Kampmann, Beate; Gambian Pertussis Study Team; members of the PERISCOPE consortium
(A1 Refereed original research article in a scientific journal)
A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens (2024)
- Journal of Immunological Methods
Pinto, Marta Valente; Barkoff, Alex-Mikael; Bibi, Sagida; Knuutila, Aapo; Teräsjärvi, Johanna; Clutterbuck, Elizabeth; Gimenez-Fourage, Sophie; Pagnon, Anke; van Gaans-van den Brink, Jacqueline A.M.; Corbiere, Veronique; De Montfort, Aymeric; Saso, Anja; Jobe, Haddijatou; Roetynck, Sophie; Kampmann, Beate; Simonetti, Elles; Diavatopoulos, Dimitri; Lambert, Eleonora E.; Mertsola, Jussi; Blanc, Pascal; van Els, Cécile A. C. M.; Dominic Kelly, Dominic; He, Qiushui; The PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
Bordetella pertussis isolates in Finland after acellular vaccination : serotype change and biofilm formation (2024)
- Clinical Microbiology and Infection
Niinikoski, Vili; Barkoff, Alex-Mikael; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Long-term COVID-19 vaccine- and Omicron infection-induced humoral and cell-mediated immunity (2024)
- Frontiers in Immunology
Belik, Milja; Reinholm, Arttu; Kolehmainen, Pekka; Heroum, Jemna; Maljanen, Sari; Altan, Eda; Österlund, Pamela; Laine, Larissa; Ritvos, Olli; Pasternack, Arja; Naves, Rauno A.; Iakubovskaia, Alina; Barkoff, Alex-Mikael; He, Qiushui; Lempainen, Johanna; Tähtinen, Paula A.; Ivaska, Lauri; Jalkanen, Pinja; Julkunen, Ilkka; Kakkola, Laura
(A1 Refereed original research article in a scientific journal)
Macrolide-resistant Bordetella pertussis strain identified during an ongoing epidemic, Finland, January to October 2024 (2024)
- Eurosurveillance
Miettinen, Milja; Barkoff, Alex-Mikael; Nyqvist, Aino; Savolainen-Kopra, Carita; Antikainen, Jenni; Mertsola, Jussi; Ivaska, Lauri; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia (2024)
- Emerging Infectious Diseases
Barkoff, Alex-Mikael; Kastrin, Tamara; Seme, Katja; Vitek, Marta Grgič; Mertsola, Jussi; He, Qiushui
(A1 Refereed original research article in a scientific journal)
Antibody avidity to pertussis toxin after acellular pertussis vaccination and infection (2023)
- Emerging microbes & infections
Knuutila Aapo, Dalby Tine, Ahvenainen Niina, Barkoff Alex-Mikael, Jørgensen Charlotte Sværke, Fuursted Kurt, Mertsola Jussi, He Qiushui
(A1 Refereed original research article in a scientific journal)
Automated EuroFlow approach for standardized in-depth dissection of human circulating B-cells and plasma cells (2023)
- Frontiers in Immunology
Delgado Alejandro H., Fluxa Rafael, Perez-Andres Martin, Diks Annieck M., van Gaans van den Brink Jacqueline A. M., Barkoff Alex-Mikael, Blanco Elena, Torres-Valle Alba, Berkowska Magdalena A., Grigore Georgiana, van Dongen J. . J. . M., Orfao Alberto; on behalf of The PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
Effect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants (2023)
- Emerging microbes & infections
Knuutila Aapo, Barkoff Alex Mikael, Ivaska Lauri, Tenhu Elina, Teräsjärvi Johanna, van Gageldonk Pieter, Buisman Annemarie, Mertsola Jussi, He Qiushui; and PERISCOPE consortium
(A1 Refereed original research article in a scientific journal)
Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria- acellular pertussis vaccine: a randomised, double-blind, phase 2b trial (2023)
- Lancet
Keech Cheryl, Miller Vicki E, Rizzardi Barbara, Hoyle Christopher, Pryor Melinda J, Ferrand Jonathan, Solovay Ken, Thalen Marcel, Noviello Stephanie, Goldstein Peter, Gorringe Andrew, Cavell Breeze, He Qiushui, Barkoff Alex-Mikael, Rubin Keith, Locht Camille
(A1 Refereed original research article in a scientific journal)
Pastern dermatitis outbreak associated with toxigenic and non-toxigenic Corynebacterium diphtheriae and non-toxigenic Corynebacterium ulcerans at a horse stable in Finland, 2021 (2023)
- Zoonoses and Public Health
Grönthal TSC, Lehto AK, Aarnio SS, Eskola EK, Aimo-Koivisto EM, Karlsson T, Koskinen HI, Barkoff AM, He Q, Lienemann T, Rimhanen-Finne R, Mykkänen A
(A1 Refereed original research article in a scientific journal)
Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (2023)
- Journal of Clinical Microbiology
Knuutila Aapo, Harju Inka, Korhonen Suvi, Mäkelä Joonatan, Backström Lucas, Barkoff Alex-Mikael, He Qiushui
(B1 Non-refereed article in a scientific journal)
Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood (2022)
- Frontiers in Immunology
van der Pan Kyra, de Bruin-Versteeg Sandra, Damasceno Daniela, Hernandez-Delgado Alejandro, van der Sluijs-Gelling Alita J, van den Bossche Wouter BL, de Laat Inge F, Diez Paula, Naber Birgitta AE, Diks Annieck M, Berkowska Magdalena A, de Mooij Bas, Groenland Rick J, de Bie Fenna J, Khatri Indu, Kassem Sara, de Jager Anniek L, Louis Alesha, Almeida Julia, van Gaans-van den Brink Jacqueline AM, Barkoff Alex-Mikael, He Qiushui, Ferwerda Gerben, Versteegen Pauline, Berbers Guy AM, Orfao Alberto, van Dongen Jacques JM, Teodosio Cristina
(A1 Refereed original research article in a scientific journal)
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis (2022)
- Science Translational Medicine
Lefrancq Noémie, Bouchez Valérie, Fernandes Nadia, Barkoff Alex-Mikael, Bosch Thijs, Dalby Tine, Åkerlund Thomas, Darenberg Jessica, Fabianova Katerina, Vestrheim Didrik F., Fry Norman K., González-López Juan Jose, Gullsby Karolina, Habington Adele, He Qiushui, Litt David, Martini Helena, Piérard Denis, Stefanelli Paola, Stegger Marc, Zavadilova Jana, Armatys Nathalie, Landier Annie, Guillot Sophie, Hong Samuel L., Lemey Philippe, Parkhill Julian, Toubiana Julie, Cauchemez Simopn, Salje Henrik, Brisse Sylvain
(A1 Refereed original research article in a scientific journal)
Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges (2022)
- Antibiotics
Ivaska Lauri, Barkoff Alex-Mikael, Mertsola Jussi, He Qiushui
(A2 Refereed review article in a scientific journal )
Memory B Cell Activation Induced by Pertussis Booster Vaccination in Four Age Groups of Three Countries (2022)
- Frontiers in Immunology
Versteegen Pauline, Barkoff Alex-Mikael, Valente Pinto Marta, Van De Kasteele Jan, Knuutila Aapo, Bibi Sagida, De Rond Lia, Teräsjärvi Johanna, Sanders Katherine, De Zeeuw-Brouwer Mary-lene, Luoto Raakel, Ten Hulscher Hinke, Clutterbuck Elizabeth A., Sanders Elisabeth A. M., Mertsola Jussi, Berbers Guy A. M., He Qiushui, Kelly Dominic F., Buisman Anne-Marie; PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups (2022)
- Emerging microbes & infections
Knuutila Aapo, Versteegen Pauline, Barkoff Alex-Mikael, van Gageldonk Pieter, Mertsola Jussi, Berbers Guy, He Qiushui; PERISCOPE Consortium
(A1 Refereed original research article in a scientific journal)
Whole blood based point-of-care assay for the detection of anti-pertussis toxin IgG antibodies (2022)
- Journal of Immunological Methods
Knuutila Aapo, Rautanen Carita, Barkoff Alex-Mikael, Mertsola Jussi, He Qiushui
(A1 Refereed original research article in a scientific journal)