Refereed journal article or data article (A1)
Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA
List of Authors: Viitanen AM, Lahesmaa-Rantala R, Weiss E, Toivanen A
Publication year: 1988
Journal: Journal of Rheumatology
Journal name in source: The Journal of rheumatology
Journal acronym: J Rheumatol
Volume number: 15
Issue number: 7
Start page: 1123
End page: 5
Number of pages: 3
ISSN: 0315-162X
Abstract
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
UTU Research Portal