A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prenatal Metformin Exposure in Mice Programs the Metabolic Phenotype of the Offspring during a High Fat Diet at Adulthood
Tekijät: Salomaki H, Vahatalo LH, Laurila K, Jappinen NT, Penttinen AM, Ailanen L, Ilyasizadeh J, Pesonen U, Koulu M
Kustantaja: PUBLIC LIBRARY SCIENCE
Julkaisuvuosi: 2013
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: PLOS ONE
Lehden akronyymi: PLOS ONE
Numero sarjassa: 2
Vuosikerta: 8
Numero: 2
Sivujen määrä: 12
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0056594
Tiivistelmä
Conclusions: The present study shows that prenatal metformin exposure causes long-term programming effects on the metabolic phenotype during high fat diet in mice. This should be taken into consideration when using metformin as a therapeutic agent during pregnancy.
Conclusions: The present study shows that prenatal metformin exposure causes long-term programming effects on the metabolic phenotype during high fat diet in mice. This should be taken into consideration when using metformin as a therapeutic agent during pregnancy.
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