A1 Journal article – refereed
α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction
List of Authors: Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E
Publisher: OXFORD UNIV PRESS
Publication year: 2013
Journal: Cardiovascular Research
Journal name in source: CARDIOVASCULAR RESEARCH
Journal acronym: Cardiovasc Res
Number in series: 2
Volume number: 97
Issue number: 2
ISSN: 0008-6363
eISSN: 1755-3245
Abstract
The present study identifies -MSH and endothelial MC1 receptors as a new signalling pathway contributing to the regulation of NO availability and vascular function. These findings suggest applicability of -MSH analogues for therapeutic use in pathological conditions that are characterized by vascular dysfunction.