A1 Journal article – refereed
Middle age self-report risk score predicts cognitive functioning and dementia in 20–40 years

List of Authors: Eero Vuoksimaa,Juha O. Rinne,Noora Lindgren,Kauko Heikkilä,Markku Koskenvuo,Jaakko Kaprio
Publisher: [Amsterdam] : Elsevier B.V., [2015]-
Publication year: 2016
Journal: Alzheimer's & dementia: diagnosis, assessment & disease monitoring
Volume number: 4
Issue number: 14


Introduction: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.

Methods: We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.

Results: The prevalence of dementia was 10% after a mean follow-up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow-up of 39 years in the replication sample.

Discussion: Self-report risk score predicted cognitive functioning and dementia risk 20–40 years later.

Last updated on 2019-21-08 at 20:02