A1 Journal article – refereed
Synthesis of 3',5'-Cyclic Phosphate and Thiophosphate Esters of 2'-C-Methyl Ribonucleosides




List of Authors: Leisvuori A, Ahmed Z, Ora M, Beigelman L, Blatt L, Lonnberg H
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2012
Journal: Helvetica Chimica Acta
Journal name in source: HELVETICA CHIMICA ACTA
Journal acronym: HELV CHIM ACTA
Number in series: 9
Volume number: 95
Issue number: 9
Number of pages: 9
ISSN: 0018-019X

Abstract
2'-C-Methylnucleosides are known to exhibit antiviral activity against Hepatitis C virus. Since the inhibitory activity depends on their intracellular conversion to 5'-triphosphates, dosing as appropriately protected 5'-phosphates or 5'-phosphorothioates appears attractive. For this purpose, four potential pro-drugs of 2'-C-methylguanosine, i.e., 3',5'-cyclic phosphorothioate of 2'-C-methylguanosine and 2'-C,O6-dimethylguanosine, 1 and 2, respectively, the S-[(pivaloyloxy)methyl] ester of 2'-C,O6-dimethylguanosine 3',5'-cyclic phosphorothioate and the O-methyl ester of 2'-C,O6-dimethylguanosine 3',5'-cyclic phosphate, 3 and 4, respectively, have been prepared.


Research Areas


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Last updated on 2019-21-08 at 22:40