Hannu Aronen
M.D., M.Sc. (Eng), Ph.D.

Areas of expertise
Medical Imaging; Magnetic Resonance Imaging

Biography


Degrees and competences

  • Licentiate of Medicine, University of Helsinki 18 Jan 1983
  • M.Sc. (Diplomi-insinööri) Helsinki University of Technology, Department
  • of Technical Physics 29 Nov 1988
  • Doctor of Medical Sciences, University of Helsinki 8 Jun 1990
  • Specialist in Radiology 26 Mar 1991
  • Subspecialist in Medical Administration 3 Dec 2002
  • Docent in Radiology, University of Helsinki 28 Dec 1995
  • Docent in Functional Medical Imaging, Helsinki Univ. of Technology 1 Mar 1998

Current Tasks

  • Professor and Chair of Radiology, University of Turku, Finland 1 Apr 2006
  • Chief Radiologist (Ylilääkäri), Turku University Hospital 1 Jan 2009

Previous tasks

  • Post Doctoral Researche (35 months), Harvard Medical School, Massachusetts General Hospital, NMR Center, Boston, MA, USA, 1990-93
  • The University in Helsinki, Assistant Professor of Radiology 1993-1996
  • The University of Kuopio, Assosiate Professor of Radiology 1997-1998
  • The University of Kuopio, Professor of Radioloty 1998-2002
  • Leader of research group “Functional Brain Imaging Unit”, which was one of the six groups forming the Helsinki Brain Research Centre, a Centre of Excellence funded by the Academy of Finland and headed by Professor Risto Näätänen. 2002-2007



Research



In the mid-1980s I began to study
magnetic resonance flow phenomena using an experimental flow phantom. With the
help of a Fogarty grant from the NIH, I began MRI perfusion and diffusion work
under the supervision of Professors Bruce Rosen and Thomas Brady and in
collaboration with the late Associate Professor John Belliveau at the Harvard
Medical School-Massachusetts General Hospital NMR Center. We made two important scientific findings: high cerebral blood volume evaluated by MRI CBV imaging is strongly associated with the grade of human
gliomas (Aronen et al. Radiology 1994) and high cerebral blood volume is
associated with high glucose uptake evaluated by means of PET FDG studies,
indicating an association of capillary density and energy metabolism in human
gliomas (Aronen et al. Clinical Cancer Research 2000).

I continued my collaboration with the MGH NMR Center,particularly with Associate Professor Belliveau until he passed February 14, 2014. Upon returning to Finland in 1993 I immediately started my own research group, beginning in Helsinki, then in 1997 in Kuopio
and since 2007 also in Turku. We demonstrated the usefulness of magnetization transfer and spin locking
techniques in the characterization of head and neck tumors (Radiology
1996;200:369-375). We also evaluated MR imaging in the diagnosis of pelvic
inflammatory disease (Radiology 1999;210:209-216) and MR imaging of Achilles
tendon problems (AJR 1999;173:323-328, AJR 2000;175:251-260). We were able to
demonstrate the usefulness of combined perfusion and diffusion MR imaging in
acute (Stroke 1999;30:1583-1590 and Radiology 2000;217:886-894) and hyperacute
(Stroke 2005;36:44-49) stroke patients. We have addressed the potential of
perfusion MRI studies in the evaluation of coronary artery disease patients
(Circulation 1997;96:2859-2867) and myocardial viability (Radiology
2000;217:729-736). One important direction of our research has been the
comparison and combination of MEG and fMRI studies (Hum Brain Map 1999;8:13-27,
Radiology 2006;241:213-22). My research group has contributed to the
methodological development and evaluation of susceptibility contrast perfusion
(Mag Reson Med 2002;47:973-981) together with Professor Leif Østergaard (Århus University
Hospital). We have
developed and evaluated effective fMRI analysis methods based on contextual
clustering (IEEE T Med Imaging 2001;20:403-414 and NeuroImage 2001;13:459-471)
and permutation (NeuroImage 2006;32:654-664).


Together with Professor Synnöve
Carlson we have imaged the primarily frontoparietal network active during the
visuospatial (Cerebral Cortex 1998;8:743-752) and audiospatial (Cerebral Cortex
2000;10:889-898) working memory tasks. During the years 2002-2007 my
research group “Functional Brain Imaging Unit” was one of the six groups
forming the Helsinki Brain Research Centre, a Centre of Excellence funded by
the Academy of Finland and headed by Professor Risto
Näätänen.
A recent focus of my research has
been the MR imaging of prostate cancer. A part of the project is being carried
out in collaboration with the Turku PET Centre (J Nucl Med 2010;51:1676-83, Eur
J Radiol. 2012 Nov;81(11):2966-72, Acta
Oncol 2016;55:59-67). We
performed more than 800 research prostate MRI scans since 2010. We have
finalized two prospective registered clinical trials in Turku. (JMRI 2015;41:1116-1124, JMRI 2017;46:1089-1095)
and published 17 original articles on the subject. In our studies a short MRI
protocol consisting of T2-weighted and diffusion weighted imaging was shown to
be a very accurate tool for the detection and characterization of clinically
significant prostate cancer. Utilizing our preliminary version of algorithms
based on machine learning we have been able to develop semiautomatic methods
for the analysis of prostate cancer MRI data sets.






Publications
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IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole-mount prostatectomy sections and implications for focal therapy (2019)
Journal of Magnetic Resonance Imaging
Merisaari H., Jambor I., Ettala O., Boström P.J., Montoya Perez I., Verho J., Kiviniemi A., Syvänen K., Kähkönen E., Eklund L., Pahikkala T., Vainio P., Saunavaara J., Aronen H.J., Taimen P.
(
A1 Journal article – refereed)

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up (2018)
Annals of Oncology
Casali P., Abecassis N., Bauer S., Biagini R., Bielack S., Bonvalot S., Boukovinas I., Bovee J., Brodowicz T., Broto J., Buonadonna A., De Álava E., Dei Tos A., Del Muro X., Dileo P., Eriksson M., Fedenko A., Ferraresi V., Ferrari A., Ferrari S., Frezza A., Gasperoni S., Gelderblom H., Gil T., Grignani G., Gronchi A., Haas R., Hannu A., Hassan B., Hohenberger P., Issels R., Joensuu H., Jones R., Judson I., Jutte P., Kaal S., Kasper B., Kopeckova K., Krákorová D., Le Cesne A., Lugowska I., Merimsky O., Montemurro M., Pantaleo M., Piana R., Picci P., Piperno-Neumann S., Pousa A., Reichardt P., Robinson M., Rutkowski P., Safwat A., Schöffski P., Sleijfer S., Stacchiotti S., Sundby Hall K., Unk M., Van Coevorden F., Van Der Graaf W., Whelan J., Wardelmann E., Zaikova O., Blay J., Casali P., Blay J., Zaikova O., Wardelmann E., Whelan J.
(
A1 Journal article – refereed)

Magneettikuvauslähetteen merkitys (2018)
Duodecim
Aronen H
(
D1 Article in a trade journal)

Prospective evaluation of 18F-FACBC PET/CT and PET/MRI versus multiparametric MRI in intermediate- to high-risk prostate cancer patients (FLUCIPRO trial) (2018)
European Journal of Nuclear Medicine and Molecular Imaging
Jambor I, Kuisma A, Kähkönen E, Kemppainen J, Merisaari H, Eskola O, Teuho J, Perez IM, Pesola M, Aronen HJ, Boström PJ, Taimen P, Minn H
(
A1 Journal article – refereed)

Fitting methods for intravoxel incoherent motion imaging of prostate cancer on region of interest level: Repeatability and gleason score prediction (2017)
Magnetic Resonance in Medicine
Harri Merisaari, Parisa Movahedi, Ileana M. Perez, Jussi Toivonen, Marko Pesola, Pekka Taimen, Peter J. Boström, Tapio Pahikkala, Aida Kiviniemi, Hannu J. Aronen, Ivan Jambor
(
A1 Journal article – refereed)

Novel Biparametric MRI and Targeted Biopsy Improves Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer (IMPROD Trial) (2017)
Journal of Magnetic Resonance Imaging
Jambor I, Bostrom PJ, Taimen P, Syvanen K, Kahkonen E, Kallajoki M, Perez IM, Kauko T, Matomaki J, Ettala O, Merisaari H, Kiviniemi A, Dean PB, Aronen HJ
(
A1 Journal article – refereed)

Radiomic features for prostate cancer detection on MRI differ between the transition and peripheral zones: Preliminary findings from a multi-institutional study (2017) Ginsburg SB, Algohary A, Pahwa S, Gulani V, Ponsky L, Aronen HJ, Boström PJ, Böhm M, Haynes AM, Brenner P, Delprado W, Thompson J, Pulbrock M, Taimen P, Villani R, Stricker P, Rastinehad AR, Jambor I, Madabhushi A
(
A1 Journal article – refereed)

Diffusion Weighted Imaging of Prostate Cancer: Prediction of Cancer using Texture Features from Parametric Maps of the Monoexponential and Kurtosis functions (2016) 2016 Sixth International Conference on Image Processing Theory, Tools and Applications (IPTA) Ileana Montoya Perez, Jussi Toivonen, Parisa Movahedi, Harri Merisaari, Marko Pesola, Pekka Taimen, Peter J. Boström, Aida Kiviniemi, Hannu J. Aronen, Tapio Pahikkala, Ivan Jambor
(
A4 Article in conference proceedings)

Diffusion weighted imaging of prostate cancer xenografts: comparison of bayesian modeling and independent least squares fitting (2016) Parisa Movahedi, Hanne Hakkarainen, Harri Merisaari, Heidi Liljenbäck, Helena Virtanen, Hannu Juhani Aronen, Heikki Minn, Matti Poutanen, Anne Roivainen, Timo Liimatainen, Ivan Jambor
(
B3 Article in conference proceedings)

Patient-specific pharmacokinetic parameter estimation on dynamic contrast-enhanced MRI of prostate: Preliminary evaluation of a novel AIF-free estimation method (2016) Ginsburg SB, Taimen P, Merisaari H, Vainio P, Boström PJ, Aronen HJ, Jambor I, Madabhushi A
(
A1 Journal article – refereed)

Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial (2016)
Acta Oncologica
Ivan Jambor, Anna Kuisma, Susan Ramadan, Riikka Huovinen, Minna Sandell, Sami Kajander, Jukka Kemppainen, Esa Kauppila, Joakim Auren, Harri Merisaari, Jani Saunavaara, Tommi Noponen, Heikki Minn, Hannu J. Aronen, Marko Seppänen
(
A1 Journal article – refereed)

Relaxation along fictitious field, diffusion-weighted imaging, and T2 mapping of prostate cancer: Prediction of cancer aggressiveness (2016)
Magnetic Resonance in Medicine
Jambor I, Pesola M, Merisaari H, Taimen P, Boström PJ, Liimatainen T, Aronen HJ
(
A1 Journal article – refereed)

Rotating frame relaxation imaging of prostate cancer: Repeatability, cancer detection, and Gleason score prediction (2016)
Magnetic Resonance in Medicine
Jambor I, Pesola M, Taimen P, Merisaari H, Boström PJ, Minn H, Liimatainen T, Aronen HJ
(
A1 Journal article – refereed)

Stratification of aggressive prostate cancer from indolent disease-Prospective controlled trial utilizing expression of 11 genes in apparently benign tissue (2016)
Urologic Oncology: Seminars and Original Investigations
Alinezhad S, Vaananen RM, Tallgren T, Perez IM, Jambor I, Aronen H, Kahkonen E, Ettala O, Syvanen K, Nees M, Kallajoki M, Taimen P, Bostrom PJ, Pettersson K
(
A1 Journal article – refereed)

Diffusion-weighted imaging of prostate cancer: effect of b-value distribution on repeatability and cancer characterization (2015)
Magnetic Resonance Imaging
Merisaari H, Toivonen J, Pesola M, Taimen P, Boström PJ, Pahikkala T, Aronen HJ, Jambor I
(
A1 Journal article – refereed)

Evaluation of different mathematical models for diffusion-weighted imaging of normal prostate and prostate cancer using high b-values: A repeatability study (2015)
Magnetic Resonance in Medicine
Jambor Ivan, Merisaari Harri, Taimen Pekka, Boström Peter, Minn Heikki, Pesola Marko, Aronen Hannu Juhani
(
A1 Journal article – refereed)

Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2: Correlation with Gleason score and repeatability of region of interest analysis (2015)
Magnetic Resonance in Medicine
Jussi Toivonen, Harri Merisaari, Marko Pesola, Pekka Taimen, Peter J. Boström, Tapio Pahikkala, Hannu J. Aronen, Ivan Jambor
(
A1 Journal article – refereed)

Prebiopsy multiparametric 3T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy (2015)
Journal of Magnetic Resonance Imaging
Ivan Jambor, Esa Kähkönen, Pekka Taimen, Harri Merisaari, Jani Saunavaara, Kalle Alanen, Branislav Obsitnik, Heikki Minn, Viera Lehotska, Hannu J. Aronen
(
A1 Journal article – refereed)

In memoriam : Martti Johannes Kormano 30.12.1941-5.11.2013 (2014)
Suomen Lääkärilehti
Dean P, Aronen H, Svedström E
(
O2 Other)


Last updated on 2019-22-05 at 02:17