Markus Juonala

Professor, Internal Medicine (Department of Clinical Medicine)

Areas of expertise
Internal medicine; endocrinology; cardiovascular risk


Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute

His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal). 


Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.



Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs

Special interest areas: Acute internal medicine, endocrinology, lipidology


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Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood (2019) Pirkko J. Pussinen, Susanna Paju, Jaana Koponen, Jorma S. A. Viikari, Leena Taittonen, Tomi Laitinen, David P. Burgner, Mika Kähönen, Nina Hutri-Kähönen, Olli T. Raitakari, Markus Juonala
A1 Journal article – refereed)

Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study (2019)
Vähämurto L, Pahkala K, Magnussen CG, Hutri-Kähönen N, Kähönen M, Laitinen T, Taittonen L, Tossavainen P, Lehtimäki T, Jokinen E, Telama R, Rönnemaa T, Viikari J, Juonala M, Raitakari OT
A1 Journal article – refereed)

Cross-sectional associations between Ideal Cardiovascular Health scores and vascular phenotypes in 11- to 12-year-olds and their parents: The Longitudinal Study of Australian Children (2019)
International Journal of Cardiology
Richard S. Liu, Melissa Wake, Anneke Grobler, Michael Cheung, Kate Lycett, Sarath Ranganathan, Ben Edwards, Terence Dwyer, Peter Azzopardi, Markus Juonala, David P. Burgner
A1 Journal article – refereed)

Discovery of mitochondrial DNA variants associated with genome-wide blood cell gene expression: a population-based mtDNA sequencing study (2019)
Human Molecular Genetics
Jaakko Laaksonen, Ilkka Seppälä, Emma Raitoharju, Nina Mononen, Leo-Pekka Lyytikäinen, Melanie Waldenberger, Thomas Illig, Maija Lepistö, Henrikki Almusa, Pekka Ellonen, Nina Hutri-Kähönen, Markus Juonala, Mika Kähönen, Olli Raitakari, Jukka T. Salonen, Terho Lehtimäki
A1 Journal article – refereed)

Glycoprotein acetyls (GlycA) at 12 months are associated with high-sensitivity C-reactive protein and early life inflammatory immune measures (2019)
Pediatric Research
Collier F, Ellul S, Juonala M, Ponsonby AL, Vuillermin P, Saffery R, Burgner D, Carlin J, Ranganathan S, Sly P, Tang MM, Allen K, Harrison LC, Dwyer T
B1 Journal article)

IDO activity forecasts obesity in females in 10-year follow-up study: the Cardiovascular Risk in Young Finns study (2019)
Thrombosis Research
P. Niinisalo, O.T.Raitakari, M. Kähonen, J. Viikari, M. Juonala, R. Kaaja
O2 Other)

Inflammatory diet and preclinical cardiovascular phenotypes in 11–12 year-olds and mid-life adults: A cross-sectional population-based study (2019)
Addison Davis, Richard Liu, Jessica A.Kerr, Melissa Wake, Anneke Grobler, Markus Juonala, Mengjiao Liu, Louise Baur, David Burgner, Kate Lycett
A1 Journal article – refereed)

Physical activity from childhood to adulthood and cognitive performance in midlife (2019)
Medicine and Science in Sports and Exercise
Hakala J.O., Rovio S.P., Pahkala K., Nevalainen J., Juonala M., Hutri-Kähönen N., Heinonen O.J., Hirvensalo M., Telama R., Viikari J.S., Tammelin T.H., Raitakari O.T.
A1 Journal article – refereed)

Sex and puberty-related differences in metabolomic profiles associated with adiposity measures in youth with obesity (2019)
Christoph Saner, Brooke E. Harcourt, Ahwan Pandey, Susan Ellul, Zoe McCallum, Kung-Ting Kao, Celia Twindyakirana, Anke Pons, Erin J. Alexander, Richard Saffery, David P. Burgner, Markus Juonala, Matthew A. Sabin
A1 Journal article – refereed)

The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study (2019)
Scientific Reports
Karjalainen J-P., Mononen N., Hutri-Kähönen N., Lehtimäki M., Juonala M., Ala-Korpela M., Kähönen M., Raitakari O., Lehtimäki T.
A1 Journal article – refereed)

The great leap backward: changes in the jumping performance of Australian children aged 11−12-years between 1985 and 2015 (2019)
Journal of Sports Sciences
Brooklyn J. Fraser, Leigh Blizzard, Grant R. Tomkinson, Kate Lycett, Melissa Wake, David Burgner, Sarath Ranganathan, Markus Juonala, Terence Dwyer, Alison J. Venn, Tim Olds, Costan G. Magnussen
A1 Journal article – refereed)

Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness (2019)
Juha Koskinen, Markus Juonala, Terence Dwyer, Alison Venn, Janina Petkeviciene, Indrė Čeponienė, Lydia Bazzano, Wei Chen, Matthew A. Sabin, Trudy L. Burns, Jorma S.A. Viikari, Jessica G. Woo, Elaine M. Urbina, Ronald Prineas, Nina Hutri-Kähönen, Alan Sinaiko, David R. Jacobs, Jr, Julia Steinberger, Stephen Daniels, Olli Raitakari, Costan G. Magnussen
A1 Journal article – refereed)

Youth and Long-Term Dietary Calcium Intake With Risk of Impaired Glucose Metabolism and Type 2 Diabetes in Adulthood (2019)
Journal of Clinical Endocrinology and Metabolism
Feitong Wu, Markus Juonala, Katja Pahkala, Marie-Jeanne Buscot, Matthew A Sabin, Niina Pitkänen, Tapani Rönnemaa, Antti Jula, Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen,Jorma S A Viikari, Olli T Raitakari, Costan G Magnussen
A1 Journal article – refereed)

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome (2018)
New England Journal of Medicine
Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM; ODYSSEY OUTCOMES Committees and Investigators
A1 Journal article – refereed)

A network approach to the analysis of psychosocial risk factors and their association with health (2018)
Journal of Health Psychology
Marko Elovainio, Christian Hakulinen, Laura Pulkki-Råback, Markus Juonala, Olli Raitakari
A1 Journal article – refereed)

Aortic sinus diameter in middle age is associated with body size in young adulthood (2018)
Hernesniemi JA, Heiskanen J, Ruohonen S, Kartiosuo N, Hutri-Kähönen N, Kähönen M, Jokinen E, Tossavainen P, Kallio M, Laitinen T, Lehtimäki T, Viikari JSA, Juonala M, Raitakari OT
A1 Journal article – refereed)

Association of Youth Triponderal Mass Index vs Body Mass Index with Obesity-Related Outcomes in Adulthood (2018)
JAMA Pediatrics
Feitong Wu, Marie-Jeanne Buscot, Markus Juonala, Nina Hutri-Kähönen, Jorma S. A. Viikari, Olli T. Raitakari, Costan G. Magnussen
A1 Journal article – refereed)

BMI Trajectories Associated With Resolution of Elevated Youth BMI and Incident Adult Obesity (2018)
Buscot MJ, Thomson RJ, Juonala M, Sabin MA, Burgner DP, Lehtimäki T, Hutri-Kähönen N, Viikari JSA, Jokinen E, Tossavainen P, Laitinen T, Raitakari OT, Magnussen CG
A1 Journal article – refereed)

Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study (2018)
Annals of Medicine
Feitong Wu, Markus Juonala, Niina Pitkänen, Antti Jula, Terho Lehtimäki, Matthew A. Sabin, Katja Pahkala, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen, Jorma S. A. Viikari, Costan G. Magnussen, Olli T. Raitakari
A1 Journal article – refereed)

Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study (2018)
Journal of the American Heart Association
Robyn J. Tapp, Alun D. Hughes, Mika Kähönen, Tien Yin Wong, Nicholas Witt, Terho Lehtimäki, Nina Hutri‐Kähönen, Pinki Sahota, Markus Juonala, Olli T. Raitakari
A1 Journal article – refereed)

Last updated on 2019-19-07 at 02:20