Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Brachial-cuff excess pressure is associated with carotid intima-media thickness among Australian children: a cross-sectional population study




Julkaisun tekijätPeng Xiaoqing, Picone Dean S., Schultz Martin G., Cai Guoqi, Wake Melissa, Burgner David P., Mynard Jonathan P., Ellul Susan, Cheung Michael, Juonala Markus, Sharman James E.

KustantajaSpringer Nature

Julkaisuvuosi2021

JournalHypertension Research

Tietokannassa oleva lehden nimiHYPERTENSION RESEARCH

Lehden akronyymiHYPERTENS RES

Volyymi44

Aloitussivu541

Lopetussivun numero549

Sivujen määrä9

ISSN0916-9636

DOIhttp://dx.doi.org/10.1038/s41440-020-00576-z

Verkko-osoitehttps://www.nature.com/articles/s41440-020-00576-z

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/69175274


Tiivistelmä

Reservoir pressure parameters (i.e., reservoir pressure [RP] and excess pressure [XSP]) independently predict cardiovascular events in adults, but this has not been investigated in children. This study aimed to determine (1) the association of reservoir pressure parameters with carotid intima-media thickness (carotid IMT), a preclinical vascular phenotype, and (2) whether a multivariable regression model with or without reservoir pressure parameters fits better for estimating carotid IMT in children. Study participants were 11–12-year-old children (n = 1231, 50% male) from the Child Health CheckPoint study, a cross-sectional substudy of the population-based Longitudinal Study of Australian Children. RP and XSP were obtained using brachial-cuff oscillometry (SphygmoCor XCEL, AtCor, Sydney). Carotid IMT was quantified by vascular ultrasonography. XSP was associated with carotid IMT after adjusting for confounders including age, sex, BMI z-score, heart rate, pubertal stage, moderate-to-vigorous physical activity, and mean arterial pressure (β = 0.93 µm, 95% CI 0.30–1.56 for XSP peak and β = 0.04 µm, 95% CI 0.01–0.08 for XSP integral). The results of the likelihood ratio test indicated a trend that the model with XSP and the above confounders fit better than a similar model without XSP for estimating carotid IMT. Our findings indicate that brachial-cuff device-measured XSP is associated with carotid IMT independent of conventional cardiovascular risk factors, including standard BP. This implies that a clinically convenient cuff approach could provide meaningful information for the early assessment of cardiovascular risk among children.


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Last updated on 2022-03-03 at 11:20