Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)

Anthracyclines: biosynthesis, engineering and clinical applications




Julkaisun tekijätHulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko

KustantajaRoyal Society of Chemistry

Julkaisuvuosi2022

JournalNatural Product Reports

Tietokannassa oleva lehden nimiNATURAL PRODUCT REPORTS

Lehden akronyymiNAT PROD REP

Volyymi39

Julkaisunumero4

Aloitussivu814

Lopetussivun numero841

Sivujen määrä28

ISSN0265-0568

eISSN1460-4752

DOIhttp://dx.doi.org/10.1039/d1np00059d


Tiivistelmä
Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural products that harbour potent antiproliferative activities. Doxorubicin has been widely used as an anticancer agent in the clinic for several decades, but its use is restricted due to severe side-effects such as cardiotoxicity. Recent studies into the mode-of-action of anthracyclines have revealed that effective cardiotoxicity-free anthracyclines can be generated by focusing on histone eviction activity, instead of canonical topoisomerase II poisoning leading to double strand breaks in DNA. These developments have coincided with an increased understanding of the biosynthesis of anthracyclines, which has allowed generation of novel compound libraries by metabolic engineering and combinatorial biosynthesis. Coupled to the continued discovery of new congeners from rare Actinobacteria, a better understanding of the biology of Streptomyces and improved production methodologies, the stage is set for the development of novel anthracyclines that can finally surpass doxorubicin at the forefront of cancer chemotherapy.


Last updated on 2024-05-01 at 07:37