A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Fusion-positive salivary gland carcinomas
Tekijät: Skálová Alena, Hyrcza Martin D., Vanecek Tomáš, Baněčková Martina, Leivo Ilmo
Kustantaja: Wiley
Julkaisuvuosi: 2022
Journal: Genes, Chromosomes and Cancer
Tietokannassa oleva lehden nimi: GENES CHROMOSOMES & CANCER
Lehden akronyymi: GENE CHROMOSOME CANC
Vuosikerta: 61
Numero: 5
Sivujen määrä: 16
ISSN: 1045-2257
DOI: https://doi.org/10.1002/gcc.23020
Tiivistelmä
Salivary gland tumors are a rare, heterogeneous group of neoplasms that pose significant diagnostic challenges for the histopathologist. Histopathological diagnosis relies primarily on morphological assessment, with ancillary special stains and immunohistochemistry. In recent years, new defining genomic alterations have been characterized in these tumors. In particular, they include gene fusions which have shown to be tightly tumor-type specific, and thus valuable for use in diagnostically challenging cases. These discoveries also help in refining tumor classification. Furthermore, such genetic alterations may have prognostic as well as potentially therapeutic implications in the era of personalized medicine. This review aims at providing a summary of the most recent updates in this field.
Salivary gland tumors are a rare, heterogeneous group of neoplasms that pose significant diagnostic challenges for the histopathologist. Histopathological diagnosis relies primarily on morphological assessment, with ancillary special stains and immunohistochemistry. In recent years, new defining genomic alterations have been characterized in these tumors. In particular, they include gene fusions which have shown to be tightly tumor-type specific, and thus valuable for use in diagnostically challenging cases. These discoveries also help in refining tumor classification. Furthermore, such genetic alterations may have prognostic as well as potentially therapeutic implications in the era of personalized medicine. This review aims at providing a summary of the most recent updates in this field.
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