Refereed journal article or data article (A1)

Nanoparticle-based inner ear delivery systems for the treatment of hearing loss




List of Authors: Xu Xiaoyu, Wang Shengyi, Shu Yilai, Zhang Hongbo

Publisher: KeAi Communications Co.

Publication year: 2021

Journal: Smart Materials in Medicine

Journal name in source: Smart Materials in Medicine

Volume number: 2

eISSN: 2590-1834

DOI: http://dx.doi.org/10.1016/j.smaim.2021.10.002

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/68367483


Abstract

Hearing loss has become the most common sensory disorder worldwide. Despite intensive research on the pathophysiology of hearing loss, biological therapeutic approaches are limited by the anatomical and physiological characteristics of the inner ear. Challenges in inner ear drug delivery involve biotherapeutic instability, membrane inaccessibility and delivery non-specificity. With the development of nanotechnology, the nanoparticle-based delivery systems are promising to overcome these limitations. After drugs loading and stabilization, nanoparticles can carry the drugs into the inner ear by crossing round window membrane. The surface bioconjugation of ligand endows nanoparticles with specific targeting capability. Nanoparticles with stimuli-responsive moieties can provide a controlled release manner. Together, these strategies show great potential for hearing loss treatment. Understanding the current advances of nanotechnology in hearing loss treatment will facilitate future therapeutic options and clinical applications.


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Last updated on 2022-07-04 at 16:21