A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Differences in brain changes between adults with childhood-onset epilepsy and controls: A prospective population-based study
Tekijät: Sillanpää Matti, Hermann Bruce, Rinne Juha O., Parkkola Riitta, Saarinen Maiju M., Karrasch Mira, Saunavaara Jani, Rissanen Eero, Joutsa Juho, Shinnar Shlomo
Kustantaja: Wiley
Julkaisuvuosi: 2022
Journal: Acta Neurologica Scandinavica
Tietokannassa oleva lehden nimi: ACTA NEUROLOGICA SCANDINAVICA
Lehden akronyymi: ACTA NEUROL SCAND
Vuosikerta: 145
Numero: 3
Aloitussivu: 322
Lopetussivu: 331
Sivujen määrä: 10
ISSN: 0001-6314
DOI: https://doi.org/10.1111/ane.13560
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/68365502
Purpose
To determine the impact of childhood-onset uncomplicated epilepsy (COE) on brain aging over 50-year prospective follow-up.
MethodsA population-based cohort of 41 aging subjects with COE and their 46 matched controls participated in a detailed in-person prospective assessment in 2012 and 2017 to characterize ongoing changes in the aging brain.
ResultsThe mean age of the COE participants was 63.2 years (SD 4.14, median 63.2, range 55.8–70.6) and 63.0 years (mean, SD 4.13, median 63.3, range 56.0–69.9) years for controls. Neurologic signs were significantly more common in COE participants not in remission (p = .015), and the most frequent abnormalities were cerebellar signs (p < .001). Neurologic signs in general (p = .008) and cerebellar signs in particular (p = .018) were significantly more common in focal than in generalized epilepsies. MRI white matter abnormalities were significantly associated with absence of vocational education (p = .011), and MRI hippocampal atrophy in COE subjects was associated with arterial hypertension versus normal blood pressure (p = .017). In the combined study cohort of COE subjects and controls, presenting neurologic signs increased both in the subjects and in the controls from the 2012 to 2017 study.
ConclusionsAt ultra-long-term follow-up, clinical and neuroimaging findings show tendencies to brain aging that is more accelerated in COE participants with active adult childhood-onset epilepsy, and particularly in focal epilepsy.
Ladattava julkaisu This is an electronic reprint of the original article. |