A1 Journal article – refereed

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma




List of Authors: Li NI, Mirzakhani H, Kiefer A, Koelle J, Vuorinen T, Rauh M, Yang ZQ, Krammer S, Xepapadaki P, Lewandowska-Polak A, Lukkarinen H, Zhang N, Stanic B, Zimmermann T, Kowalski ML, Jartti T, Bachert C, Akdis M, Papadopoulos NG, Raby BA, Weiss ST, Finotto S

Publisher: CELL PRESS

Publication year: 2021

Journal: iScience

Journal name in source: ISCIENCE

Journal acronym: ISCIENCE

Volume number: 24

Issue number: 10

Number of pages: 19

DOI: http://dx.doi.org/10.1016/j.isci.2021.103163

URL: https://doi.org/10.1016/j.isci.2021.103163


Abstract
RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

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Last updated on 2021-02-12 at 15:45