Refereed journal article or data article (A1)
Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma
List of Authors: Li Nina, Mirzakhani Hoomann, Kiefer Alexander, Koelle Julia, Vuorinen Tytti, Rauh Manfred, Yang Zuqin, Krammer Susanne, Xepapadaki Paraskevi, Lewandowska-Polak Anna, Lukkarinen Heikki, Zhang Nan, Stanic Barbara, Zimmermann Theodor, Kowalski Marek L, Jartti Tuomas, Bachert Claus, Akdis Mübeccel, Papadopoulos Nikolaos G, Raby Benjamin A, Weiss Scott T, Finotto Susetta
Publisher: CELL PRESS
Publication year: 2021
Journal: iScience
Journal name in source: ISCIENCE
Journal acronym: ISCIENCE
Article number: ARTN 103163
Volume number: 24
Issue number: 10
Number of pages: 19
DOI: http://dx.doi.org/10.1016/j.isci.2021.103163
URL: https://doi.org/10.1016/j.isci.2021.103163
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67875055
RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.
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