Refereed journal article or data article (A1)

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma




List of AuthorsLi Nina, Mirzakhani Hoomann, Kiefer Alexander, Koelle Julia, Vuorinen Tytti, Rauh Manfred, Yang Zuqin, Krammer Susanne, Xepapadaki Paraskevi, Lewandowska-Polak Anna, Lukkarinen Heikki, Zhang Nan, Stanic Barbara, Zimmermann Theodor, Kowalski Marek L, Jartti Tuomas, Bachert Claus, Akdis Mübeccel, Papadopoulos Nikolaos G, Raby Benjamin A, Weiss Scott T, Finotto Susetta

PublisherCELL PRESS

Publication year2021

JournaliScience

Journal name in sourceISCIENCE

Journal acronymISCIENCE

Article numberARTN 103163

Volume number24

Issue number10

Number of pages19

DOIhttp://dx.doi.org/10.1016/j.isci.2021.103163

URLhttps://doi.org/10.1016/j.isci.2021.103163

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/67875055


Abstract
RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

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Last updated on 2022-27-10 at 10:35