A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Episodic memory and cortical amyloid pathology: PET study in cognitively discordant twin pairs
Tekijät: Lindgren Noora, Kaprio Jaakko, Karjalainen Tomi, Ekblad Laura, Helin Semi, Karrasch Mira, Teuho Jarmo, Rinne Juha O, Vuoksimaa Eero
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2021
Journal: Neurobiology of Aging
Tietokannassa oleva lehden nimi: NEUROBIOLOGY OF AGING
Lehden akronyymi: NEUROBIOL AGING
Vuosikerta: 108
Aloitussivu: 122
Lopetussivu: 132
Sivujen määrä: 11
ISSN: 0197-4580
eISSN: 1558-1497
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.08.016
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S0197458021002700?via%3Dihub
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/67714933
We studied the association between episodic memory and cortical fibrillar beta-amyloid pathology within twin pairs. Using telephone-administered cognitive screening of 1415 twin pairs in a population-based older Finnish Twin Cohort study, we identified 45 (mean [SD] age 72.9 [4.0] years, 40% women) cognitively discordant same-sex twin pairs (24 dizygotic and 21 monozygotic) without neurological or psychiatric disorders other than AD or mild cognitive impairment. In-person neuropsychological testing was conducted. Cortical amyloid was measured with carbon 11-labelled Pittsburgh compound B ([11C]PiB) positron emission tomography imaging and quantified as the average standardized uptake value ratio in cortical regions affected in AD. Larger within-twin pair differences in verbal immediate (r = -0.42) and delayed free recall (r = -0.41), and visual delayed free recall (r = -0.46) were associated with larger within-twin pair differences in [11C]PiB uptake (p's < 0.01). Correlations were not significantly different in dizygotic and monozygotic pairs suggesting that the episodic memory-cortical amyloid relationship is not confounded by genetic effects. However, larger samples are needed to draw more definitive conclusions. (C) 2021 The Authors. Published by Elsevier Inc.
Ladattava julkaisu This is an electronic reprint of the original article. |