A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
Tekijät: Rajasilta Olli, Häkkinen Suvi, Björnsdotter Malin, Scheinin Noora M., Lehtola Satu J., Saunavaara Jani, Parkkola Riitta, Lähdesmäki Tuire, Karlsson Linnea, Karlsson Hasse, Tuulari Jetro J.
Kustantaja: NATURE PORTFOLIO
Julkaisuvuosi: 2021
Journal: Scientific Reports
Tietokannassa oleva lehden nimi: SCIENTIFIC REPORTS
Lehden akronyymi: SCI REP-UK
Artikkelin numero: ARTN 19182
Vuosikerta: 11
Numero: 1
Sivujen määrä: 9
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-98574-9
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/67545632
Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony and distal connectivity in the neonate brain. 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 +/- 6.28 days, 12 male). The neonates were scanned with a 6-min resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo. Seed-based connectivity analysis with multiple regression was subsequently performed with seed-ROI derived from ReHo analysis. Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (SFG) (FWE-corrected p < 0.005). Additionally, we found both positive and negative associations (p < 0.05, FWE-corrected) for maternal pre-pregnancy BMI and seed-based connectivity between left SFG and prefrontal, amygdalae, basal ganglia and insular regions. Our results imply that maternal pre-pregnancy BMI associates with local and distal functional connectivity within the neonate left superior frontal gyrus. These findings add to the evidence that increased maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
