A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Axis-I disorders and vulnerability to psychosis
Tekijät: Tanja Svirskis, Jyrki Korkeila, Markus Heinimaa, Jukka Huttunen, Tuula Ilonen, Terja Ristkari, Thomas McGlashan, Raimo K R Salokangas
Kustantaja: Elsevier
Julkaisuvuosi: 2005
Lehden akronyymi: Schizophr Res
Vuosikerta: 75
Numero: 2-3
Aloitussivu: 439
Lopetussivu: 446
DOI: https://doi.org/10.1016/j.schres.2004.11.002.
Background: The psychopathology that manifests during the prodromal phase of first-episode psychosis is varied. Little is known about the clinical diagnoses of subjects with so-called prodromal or psychotic-like symptoms.
Method: Samples of psychotic patients, first-degree relatives (FDRs) of psychotic, or severely ill patients, treatment-seeking patients, and a random community sample (in all 157 subjects) were assessed by the Structured Interview for Prodromal Symptoms (SIPS) and the SCID-I. Vulnerability to psychosis (VTP) was defined by severity of positive symptoms reported in the SIPS interview and associated with lifetime SCID-I diagnoses.
Results: The number of lifetime diagnoses received increased linearly as the SIPS symptoms approached more psychotic-like phenomena. All VTP subjects received on average 2.5, and currently prodromal subjects 2.9 lifetime SCID-I diagnoses, while the corresponding figure for non-VTP subjects was 0.7 (p<0.0001). Mood disorders and comorbid anxiety disorders were particularly common.
Conclusion: Vulnerability to psychosis seems to be associated with a high number of lifetime Axis-I diagnoses. Occurrence of anxiety disorders is remarkable, and most VTP subjects can be diagnosed with a lifetime mood disorder. VTP subjects require careful assessment of mood and anxiety symptoms and adequate treatment for their multiple disorders.