A1 Journal article – refereed

Long-term outcomes after coronary artery bypass surgery in patients with rheumatoid arthritis




List of Authors: Malmberg Markus, Palomäki Antti, Sipilä Jussi OT, Rautava Päivi, Gunn Jarmo, Kytö Ville

Publisher: TAYLOR & FRANCIS LTD

Publication year: 2021

Journal: Annals of Medicine

Journal name in source: ANNALS OF MEDICINE

Journal acronym: ANN MED

Volume number: 53

Issue number: 1

Number of pages: 8

ISSN: 0785-3890

DOI: http://dx.doi.org/10.1080/07853890.2021.1969591

URL: https://doi.org/10.1080/07853890.2021.1969591


Abstract

Objective: To investigate the long-term outcomes of coronary artery bypass grafting surgery (CABG) in patients with rheumatoid arthritis (RA).

Methods: Patients with RA (n = 378) were retrospectively compared to patients without RA (n = 7560), all treated with CABG in a multicentre, population-based cohort register study in Finland. The outcomes were studied with propensity score-matching adjustment for baseline features. The median follow-up was 9.7 years.

Results: Diagnosis of RA was associated with an increased risk of mortality after CABG compared to patients without RA (HR 1.50; CI 1.28-1.77; p < .0001). In addition, patients with RA were in higher risk of myocardial infarction during the follow-up period (HR 1.61; CI 1.28-2.04; p < .0001). Cumulative rate of repeated revascularization after CABG was 14.4% in RA patients and 12.0% in control patients (p = .060). Duration of RA before CABG (p = .011) and preoperative corticosteroid usage in RA (p = .041) were independently associated with higher mortality after CABG. There were no differences between the study groups in 30-d mortality or in the post-operative usage of cardiovascular medications.

Conclusions: RA is independently associated with worse prognosis in coronary artery disease treated with CABG. Preoperative corticosteroid use and longer RA disease duration are additional risk factors for mortality.Key messagesPatients with rheumatoid arthritis (RA) have impaired long-term outcomes after coronary artery bypass surgery (CABG).Glucocorticoid use before CABG and duration of RA are associated with higher mortality.Special attention should be paid in secondary prevention of cardiovascular disease in RA patients after CABG.


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Last updated on 2021-19-10 at 15:12