A1 Refereed original research article in a scientific journal
Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS
Authors: Kärkkäinen I, Rybnikova E, Pelto-Huikko M, Huovila AP
Publication year: 2000
Journal: Molecular and Cellular Neuroscience
Journal name in source: Molecular and cellular neurosciences
Journal acronym: Mol Cell Neurosci
Volume: 15
Issue: 6
First page : 547
Last page: 60
ISSN: 1044-7431
DOI: https://doi.org/10.1006/mcne.2000.0848
Abstract
ADAM family of metalloprotease-disintegrins, including enzymes that process TNF-alpha and beta-amyloid precursor protein, has been indicated in neuronal development, but the role of these protease/adhesion/signaling proteins in adult nervous system remains poorly understood. Present study provides a systematic examination of ADAM gene expression in rodent CNS, showing the first quantitative characterization of ADAM mRNA distribution therein. At least 17 ADAM mRNAs were expressed. Individual ADAM mRNAs and their isoforms showed strikingly different expression patterns. Expression of mRNAs for ADAM10, the putative alpha-secretase, and ADAM17 (TACE), also indicated in APP processing, was further characterized using in situ hybridization. Expression of ADAM10 mRNA was widespread, while ADAM17 showed a more restricted pattern. Altogether, the wide and differential expression of ADAM mRNAs suggests versatile roles for ADAMs in the adult CNS.
ADAM family of metalloprotease-disintegrins, including enzymes that process TNF-alpha and beta-amyloid precursor protein, has been indicated in neuronal development, but the role of these protease/adhesion/signaling proteins in adult nervous system remains poorly understood. Present study provides a systematic examination of ADAM gene expression in rodent CNS, showing the first quantitative characterization of ADAM mRNA distribution therein. At least 17 ADAM mRNAs were expressed. Individual ADAM mRNAs and their isoforms showed strikingly different expression patterns. Expression of mRNAs for ADAM10, the putative alpha-secretase, and ADAM17 (TACE), also indicated in APP processing, was further characterized using in situ hybridization. Expression of ADAM10 mRNA was widespread, while ADAM17 showed a more restricted pattern. Altogether, the wide and differential expression of ADAM mRNAs suggests versatile roles for ADAMs in the adult CNS.
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