A1 Refereed original research article in a scientific journal

Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life




AuthorsMeng Yaxing, Magnussen Costan G, Wu Feitong, Buscot Marie Jeanne, Juonala Markus, Pahkala Katja, Hutri-Kähönen Nina, Kähönen Mika, Laitinen Tomi, Viikari Jorma SA, Raitakari Olli T, Sharman James E

PublisherLIPPINCOTT WILLIAMS & WILKINS

Publishing place PHILADELPHIA

Publication year2021

JournalJournal of Hypertension

Journal name in sourceJOURNAL OF HYPERTENSION

Journal acronymJ HYPERTENS

Volume39

Issue9

First page 1865

Last page1875

Number of pages11

ISSN0263-6352

DOIhttps://doi.org/10.1097/HJH.0000000000002855

Web address http://www.doi.org/10.1097/HJH.0000000000002855

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/66931905


Abstract

Background: Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.

Methods: Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 6-18 years (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima-media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.

Results: The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima-media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.

Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.


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Last updated on 2024-26-11 at 19:55