A1 Journal article – refereed

Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life

List of Authors: Meng Yaxing, Magnussen Costan G, Wu Feitong, Buscot Marie Jeanne, Juonala Markus, Pahkala Katja, Hutri-Kähönen Nina, Kähönen Mika, Laitinen Tomi, Viikari Jorma SA, Raitakari Olli T, Sharman James E



Publication year: 2021

Journal: Journal of Hypertension

Journal name in source: JOURNAL OF HYPERTENSION

Journal acronym: J HYPERTENS

Volume number: 39

Issue number: 9

Number of pages: 11

ISSN: 0263-6352

DOI: http://dx.doi.org/10.1097/HJH.0000000000002855

URL: http://www.doi.org/10.1097/HJH.0000000000002855

Background: Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.Methods: Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 6-18 years (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima-media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.Results: The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima-media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.

Last updated on 2021-19-10 at 11:30