A1 Journal article – refereed

Length of stay following percutaneous left atrial appendage occlusion: Data from the prospective, multicenter Amplatzer Amulet Occluder Observational Study

List of Authors: Piayda Kerstin, Afzal Shazia, Nielsen-Kudsk Jens Erik, Schmidt Boris, Mazzone Patrizio, Berti Sergio, Fischer Sven, Lund Juha, Montorfano Matteo, Hildick-Smith David, Gage Ryan, Zhao Hong, Zeus Tobias


Publication year: 2021

Journal: PLoS ONE

Journal name in source: PLOS ONE

Journal acronym: PLOS ONE

Volume number: 16

Issue number: 8

Number of pages: 11

ISSN: 1932-6203

eISSN: 1932-6203

DOI: http://dx.doi.org/10.1371/journal.pone.0255721


Aims To evaluate factors influencing the length of stay in patients undergoing percutaneous left atrial appendage occlusion (LAAO).

Methods and results Patient characteristics, procedural data and the occurrence of serious adverse events were analyzed from the Amplatzer Amulet Occluder Observational Study. Patients were divided into three groups: same day (S, 0day, n = 60, 5.6%) early (E, 1day, n = 526, 48.9%), regular (R, 2-3days, n = 338, 31.4%) and late (L, >= 4days, n = 152, 14.1%) discharge and followed up for 60 days. Procedure and device related SAE during the in-hospital stay (S: 0.0% vs. E: 1.0% vs. R: 2.1% vs. L: 23%, p<0.0001) were a major trigger for a prolonged in-hospital stay. Of the 37 subjects in the late discharge group with an SAE prior to discharge, cardiac or bleeding complications were the most common underlying conditions, occurring in 26 subjects. Multinomial logistic analysis only identified HAS-BLED score as an independent influencing factor (p = 0.04) for a late discharge. After 60 days, mortality tended to be greatest in the late discharge group (S: 0.0% vs. E: 1.0% vs. R: 1.2% vs. L: 3.3%, p = 0.1066).

Conclusion Over half of the subjects receiving an Amplatzer Amulet occluder were discharged within 1 day of the implant procedure. Serious adverse events were a major trigger for a late discharge after LAAO. Increased HAS-BLED score was associated with a prolonged in-hospital stay.

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Last updated on 2021-20-10 at 14:56