A2 Refereed review article in a scientific journal
Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Infections a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature
Authors: Koskimaki J, Zhang DD, Carrion-Penagos J, Girard R, Piedad K, Polster SP, Lyne S, Stadnik A, Awad IA
Publisher: ELSEVIER SCIENCE INC
Publication year: 2020
Journal: World Neurosurgery
Journal name in source: WORLD NEUROSURGERY
Journal acronym: WORLD NEUROSURG
Volume: 136
First page : 7
Last page: 11
Number of pages: 5
ISSN: 1878-8750
DOI: https://doi.org/10.1016/j.wneu.2019.12.172
Abstract
BACKGROUND: Cavernous angiomas (CAs) are vascular malformations that may result in stroke.CASE DESCRIPTION: Herein, we evaluate a CA patient with chronic migraine who experienced 2 documented symptomatic hemorrhages after receiving respective high doses of botulinum toxin (Btx).CONCLUSIONS: Recently, bacterial lipopolysaccharide has been reported to contribute to CA development through Toll-like receptor signaling, causing hemorrhagic angiogenic proliferation. Lipopolysaccharide and Btx share a common intracellular signaling pathway driving CA development and hemorrhage. Significance of these observations is demonstrated by previous works on plasma molecules showing prognostic associations with symptomatic hemorrhages in human CA, related to the same canonical pathways. Authors suggest careful tracking of the association of Btx and hemorrhage in CA patients.
BACKGROUND: Cavernous angiomas (CAs) are vascular malformations that may result in stroke.CASE DESCRIPTION: Herein, we evaluate a CA patient with chronic migraine who experienced 2 documented symptomatic hemorrhages after receiving respective high doses of botulinum toxin (Btx).CONCLUSIONS: Recently, bacterial lipopolysaccharide has been reported to contribute to CA development through Toll-like receptor signaling, causing hemorrhagic angiogenic proliferation. Lipopolysaccharide and Btx share a common intracellular signaling pathway driving CA development and hemorrhage. Significance of these observations is demonstrated by previous works on plasma molecules showing prognostic associations with symptomatic hemorrhages in human CA, related to the same canonical pathways. Authors suggest careful tracking of the association of Btx and hemorrhage in CA patients.
UTU Research Portal