A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Precipitation of Inorganic Salts in Mitochondrial Matrix
Tekijät: Jasielec JJ, Filipek R, Dolowy K, Lewenstam A
Kustantaja: MDPI
Julkaisuvuosi: 2020
Journal: Membranes
Tietokannassa oleva lehden nimi: MEMBRANES
Lehden akronyymi: MEMBRANES-BASEL
Artikkelin numero: ARTN 81
Vuosikerta: 10
Numero: 5
Sivujen määrä: 29
DOI: https://doi.org/10.3390/membranes10050081
Tiivistelmä
In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke.
In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke.
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