A1 Refereed original research article in a scientific journal
Continuous Modeling of Calcium Transport Through Biological Membranes
Authors: Jasielec JJ, Filipek R, Szyszkiewicz K, Sokalski T, Lewenstam A
Publisher: SPRINGER
Publication year: 2016
Journal: Journal of Materials Engineering and Performance
Journal name in source: JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
Journal acronym: J MATER ENG PERFORM
Volume: 25
First page : 3285
Last page: 3290
Number of pages: 6
ISSN: 1059-9495
DOI: https://doi.org/10.1007/s11665-016-2160-y
Abstract
In this work an approach to the modeling of the biological membranes where a membrane is treated as a continuous medium is presented. The Nernst-Planck-Poisson model including Poisson equation for electric potential is used to describe transport of ions in the mitochondrial membrane-the interface which joins mitochondrial matrix with cellular cytosis. The transport of calcium ions is considered. Concentration of calcium inside the mitochondrion is not known accurately because different analytical methods give dramatically different results. We explain mathematically these differences assuming the complexing reaction inside mitochondrion and the existence of the calcium set-point (concentration of calcium in cytosis below which calcium stops entering the mitochondrion).
In this work an approach to the modeling of the biological membranes where a membrane is treated as a continuous medium is presented. The Nernst-Planck-Poisson model including Poisson equation for electric potential is used to describe transport of ions in the mitochondrial membrane-the interface which joins mitochondrial matrix with cellular cytosis. The transport of calcium ions is considered. Concentration of calcium inside the mitochondrion is not known accurately because different analytical methods give dramatically different results. We explain mathematically these differences assuming the complexing reaction inside mitochondrion and the existence of the calcium set-point (concentration of calcium in cytosis below which calcium stops entering the mitochondrion).
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