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Immunoglobulin germline gene variation and its impact on human disease




TekijätMikocziova Ivana, Greiff Victor, Sollid Ludvig M

KustantajaSPRINGERNATURE

Julkaisuvuosi2021

JournalGenes and Immunity

Tietokannassa oleva lehden nimiGENES AND IMMUNITY

Lehden akronyymiGENES IMMUN

Vuosikerta22

Aloitussivu205

Lopetussivu217

Sivujen määrä13

ISSN1466-4879

eISSN1476-5470

DOIhttps://doi.org/10.1038/s41435-021-00145-5


Tiivistelmä
Immunoglobulins (Ig) play an important role in the immune system both when expressed as antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular fluids. The advent of high-throughput sequencing methods has enabled the investigation of human Ig repertoires at unprecedented depth. This has led to the discovery of many previously unreported germline Ig alleles. Moreover, it is becoming clear that convergent and stereotypic antibody responses are common where different individuals recognise defined antigenic epitopes with the use of the same Ig V genes. Thus, germline V gene variation is increasingly being linked to the differential capacity of generating an effective immune response, which might lead to varying disease susceptibility. Here, we review recent evidence of how germline variation in Ig genes impacts the Ig repertoire and its subsequent effects on the adaptive immune response in vaccination, infection, and autoimmunity.



Last updated on 2024-26-11 at 15:44