Refereed journal article or data article (A1)

Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm




List of AuthorsPaalanne Marika, Vääräsmäki Marja, Mustaniemi Sanna, Tikanmäki Marjaana, Wehkalampi Karoliina, Matinolli Hanna-Maria, Eriksson Johan, Järvelin Marjo-Riitta, Morin-Papunen Laure, Kajantie Eero

PublisherEuropean society of endocrinology

Publication year2021

JournalEuropean Journal of Endocrinology

Journal name in sourceEuropean journal of endocrinology

Journal acronymEur J Endocrinol

Volume number185

Issue number2

Start page279

End page288

ISSN0804-4643

eISSN1479-683X

DOIhttp://dx.doi.org/10.1530/EJE-20-1462

URLhttps://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/66684804


Abstract

Abstract

Objective
It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term.

Design
The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years).

Methods
We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L).

Results
Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70).

Conclusions
Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term.


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Last updated on 2022-19-12 at 15:58