A2 Review article in a scientific journal

Genetic variations of toll-like receptors: Impact on susceptibility, severity and prognosis of bacterial meningitis

List of Authors: Zheng Kai, He Felix B., Liu Hongshan, He Qiushui

Publication year: 2021

Journal: Infection, Genetics and Evolution

Journal name in source: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Journal acronym: Infect Genet Evol

Volume number: 93

ISSN: 1567-1348

eISSN: 1567-7257

DOI: http://dx.doi.org/10.1016/j.meegid.2021.104984


Bacterial meningitis (BM) is a serious infectious disease of the central nervous system,which is mainly caused by Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Group B Streptococcus and Listeria monocytogenes. Throughout the world, BM has become one of the most lethal diseases that commonly occurs in children. Toll like receptors (TLRs) are one of the most important immune defense lines in infectious diseases, and play an essential role in host defense. Accumulating evidence shows that genetic variations in TLRs are associated with host responses in BM. This review aims to summarize the role of different TLRs and their genetic variations in the susceptibility, severity and prognosis of BM and discuss the identified risk factors for better treatment and improvement of the course and outcome of BM.

Last updated on 2021-29-09 at 15:22