Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Practical aspects of sentinel node biopsy in oral cavity cancer: all nodes that emit a signal are important

Julkaisun tekijät: Panula Elina, Hirvonen Jussi, Vahlberg Tero, Schrey Aleksi, Irjala Heikki

Kustantaja: Taylor & Francis

Julkaisuvuosi: 2021

Journal: Acta Oto-laryngologica

Tietokannassa oleva lehden nimi: ACTA OTO-LARYNGOLOGICA

Lehden akronyymi: ACTA OTO-LARYNGOL

Volyymi: 141

Julkaisunumero: 8

Sivujen määrä: 5

ISSN: 0001-6489

eISSN: 1651-2251


Rinnakkaistallenteen osoite:


Background and objectives

Sentinel node biopsy (SNB) is a safe and effective way to examine an N0 neck in early-stage oral cavity cancer (OCC). In this study, we evaluated the variables of SNB detection, surgery, and outcome.

Material and methods

Ninety-two patients with N0 OCC examined with SNB were included. Number and brightness of nodes detected on preoperative imaging and during surgery were analyzed and compared with histological findings. Patients with recurrent disease were evaluated separately and the effect of smoking and alcohol consumption was analyzed.


Eighteen patients had at least malignant cells in the sentinel lymph node (SLN); 18 patients had recurrent disease and nine patients died from the cancer. The negative predictive value of SNB was 95%. Six patients did not have metastases in the node with the strongest signal, but metastases were found in an SLN with a weaker signal. Smoking and alcohol consumption did not affect disease-specific or overall survival.

Conclusion and significance

SNB has been confirmed to be safe and effective in early stage N0 OCC. However, it is important to carefully harvest up to four hottest SLNs that emit a signal. Treatment of patients with only isolated tumor cells (ITC) in the SLN appears to be necessary.

Ladattava julkaisu

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Last updated on 2022-07-04 at 16:20